Synthesis and Characterization via Molecular Quantum Parameters of 2H‐Thiazolo[3,2‐a]pyrimidine‐3,5,7(6H)‐trione

Hamama, Wafaa S.; Ismail, Mohamed A.; Soliman, Mahmoud E.; Shaaban, Saad; Zoorob, Hanafi H.

doi:10.1002/jhet.746

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…A novel class of 2 H ‐thiazolo[3,2‐ a ]pyrimidine‐3,5,7‐(6 H )trione has been synthesized from 2‐iminothiazolidin‐4‐one in acetyl chloride with malonic acid and characterized via molecular quantum parameters using the parameterized model number 3‐semiempirical MO method (Scheme ).…”

Section: Condensed 4‐thiazolidinonesmentioning

confidence: 99%

Recent Advances in Chemistry of Condensed 4‐Thiazolidinones

Gupta

2015

Journal of Heterocyclic Chem

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The syntheses of condensed 4‐thiazolidinone and its various derivatives are reviewed for the first time. Condensed 4‐thiazolidinones are important scaffolds and versatile substrates in heterocyclic chemistry, as they can be used for the synthesis of a large variety of biologically active compounds such as thiazolotriazines and as raw material for the drug synthesis. The high reactivity of active methylene group next to the carbonyl of the thiazolidin ring represents useful targets for many organic reactions.

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Section: Condensed 4‐thiazolidinonesmentioning

confidence: 99%

Recent Advances in Chemistry of Condensed 4‐Thiazolidinones

Gupta

2015

Journal of Heterocyclic Chem

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ChemInform Abstract: Synthesis and Characterization via Molecular Quantum Parameters of 2H‐Thiazolo[3,2‐a]pyrimidine‐3,5,7(6H)‐trione (III).

et al. 2012

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Synthesis, characterization, computational simulation, biological and anticancer evaluation of Pd(II), Pt(II), Zn(II), Cd(II), and Hg(II) complexes with 2‐amino‐4‐phenyl‐5‐selenocyanatothiazol ligand

Al‐Janabi

Zaky

Yousef

et al. 2020

J Chinese Chemical Soc

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New Pd(II), Pt(II), Zn(II), Cd(II), and Hg(II) complexes were synthesized from the reaction of 4‐phenyl‐5‐selenocyanatothiazol‐2‐amine (PhSeCNH) with metal chlorides. The produced compounds were characterized by various spectroscopic techniques. The Material Studio program was used to propose the best fit atomic skeletons for the isolated solid compounds by applying density functional theory. Quantum chemical parameters were determined from such modeling. Also, the synthesized complexes were screened for their cytotoxicity in breast adenocarcinoma (MCF‐7) and human cervical (HeLa) cell lines. Furthermore, the bactericidal activity of the investigated compounds was also evaluated against Staphylococcus aureus as a Gram‐positive bacteria as well as Pseudomonas aeruginosa and Escherichia coli as Gram‐negative bacteria.

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Synthesis and Characterization via Molecular Quantum Parameters of 2H‐Thiazolo[3,2‐a]pyrimidine‐3,5,7(6H)‐trione

Cited by 4 publications

References 18 publications

Recent Advances in Chemistry of Condensed 4‐Thiazolidinones

Recent Advances in Chemistry of Condensed 4‐Thiazolidinones

ChemInform Abstract: Synthesis and Characterization via Molecular Quantum Parameters of 2H‐Thiazolo[3,2‐a]pyrimidine‐3,5,7(6H)‐trione (III).

Synthesis, characterization, computational simulation, biological and anticancer evaluation of Pd(II), Pt(II), Zn(II), Cd(II), and Hg(II) complexes with 2‐amino‐4‐phenyl‐5‐selenocyanatothiazol ligand

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