Synthesis and Characterization of a Chitosan/PVA Antimicrobial Hydrogel Nanocomposite for Responsive Wound Management Materials

Rinehart, Samantha J.; Campbell, Thomas Draper; Burke, Kevin J.; Garcia, Bianca Bonetto Moreno; Mlynarski, Amy; Brain, Samantha J.; Truffa, Julianne M.; Rago, James V.; Chura, William E.; Keleher, Jason J.

doi:10.4172/1948-5948.1000264

Cited by 27 publications

(11 citation statements)

References 24 publications

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“…Hispathological analysis was performed according to the previous reported methods with slight modification (29,30). Simply the wounds were excised from rabbits after euthanizing them on days 4, 8, 12, and 16.…”

Section: Histopathologymentioning

confidence: 99%

Fabrication, Physical Characterizations, and In Vitro, In Vivo Evaluation of Ginger Extract-Loaded Gelatin/Poly(Vinyl Alcohol) Hydrogel Films Against Burn Wound Healing in Animal Model

et al. 2020

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Crude ginger has been used to treat wounds since ancient times till nowadays. The present study aimed at designing and characterizing topical hydrogel films loaded with ginger extract for wound healing in animal model. The hydrogel films were prepared using PVA and gelatin. The prepared films were evaluated for FTIR analysis, surface morphology, pH, swelling behavior, in vitro release, and % drug content. The wound-healing activity of the extract-loaded hydrogel films was compared with commercially available Silver Sulfadiazine® cream. The drug was compatible with the selected polymers and indicated the suitability of the selected polymers for preparation of topical hydrogel films. The SEM images clearly indicated porous structure of the prepared hydrogel films. Slight changes were observed in pH, ranging from 4.98 ± 0.079 in the beginning of the study to 4.9 ± 0.58 in the end. The swelling percentage after 8 h was 257.7%. The films released 78.7 ± 1.7% of the drug in 250 min. The percent drug content was 97.78 ± 5% which did not change significantly during the storage period. The hydrogel films showed similar wound-healing activity as compared to the commercial product (p > 0.05; ANOVA), while greater wound-healing activity as compared to the control group (p < 0.05; ANOVA) evidenced by intensive collagen formation in histopathological analysis.

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Section: Histopathologymentioning

confidence: 99%

Fabrication, Physical Characterizations, and In Vitro, In Vivo Evaluation of Ginger Extract-Loaded Gelatin/Poly(Vinyl Alcohol) Hydrogel Films Against Burn Wound Healing in Animal Model

et al. 2020

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“…Some of the most common hydrogel components include polyvinyl alcohol, polyethylene glycol, poloxamers, and carboxymethyl cellulose (described in Table 2). Other hydrogels have been made using artificial bolalipids, gelatin, collagen, sericin, and other polymer matrices [98,121,124,126,127]. While there are several polymer types that are commonly used for the fabrication of hydrogels, hydrogel properties can be altered by copolymerization, cross-linking, or combining multiple polymers into the network.…”

Section: Hydrogelsmentioning

confidence: 99%

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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“…In this work, the authors have optimized the CS/PVA ratio by deposition method for incorporating Ag + and pH of the composite. This optimization has helped achieve the gradual release of Ag + , which increases the longevity of the wound dressing substrate [ 111 ]. In a similar work by Pei et al, the impact of AgNPs in wound dressing application was investigated using AgNPs-loaded silk fibroin/carboxymethyl CS composite sponge.…”

Section: Chitosan Polymer For Photonic Applicationsmentioning

confidence: 99%

Shining Light on Chitosan: A Review on the Usage of Chitosan for Photonics and Nanomaterials Research

Marpu

Benton

2018

IJMS

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Chitosan (CS) is a natural polymer derived from chitin that has found its usage both in research and commercial applications due to its unique solubility and chemical and biological attributes. The biocompatibility and biodegradability of CS have helped researchers identify its utility in the delivery of therapeutic agents, tissue engineering, wound healing, and more. Industrial applications include cosmetic and personal care products, wastewater treatment, and corrosion protection, to name a few. Many researchers have published numerous reviews outlining the physical and chemical properties of CS, as well as its use for many of the above-mentioned applications. Recently, the cationic polyelectrolyte nature of CS was found to be advantageous for stabilizing fascinating photonic materials including plasmonic nanoparticles (e.g., gold and silver), semiconductor nanoparticles (e.g., zinc oxide, cadmium sulfide), fluorescent organic dyes (e.g., fluorescein isothiocyanate (FITC)), luminescent transitional and lanthanide complexes (e.g., Au(I) and Ru(II), and Eu(III)). These photonic systems have been extensively investigated for their usage in antimicrobial, wound healing, diagnostics, sensing, and imaging applications. Highlighted in this review are the different works involving some of the above-mentioned molecular-nano systems that are prepared or stabilized using the CS polymer. The advantages and the role of the CS for synthesizing and stabilizing the above-mentioned optically active materials have been illustrated.

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Synthesis and Characterization of a Chitosan/PVA Antimicrobial Hydrogel Nanocomposite for Responsive Wound Management Materials

Cited by 27 publications

References 24 publications

Fabrication, Physical Characterizations, and In Vitro, In Vivo Evaluation of Ginger Extract-Loaded Gelatin/Poly(Vinyl Alcohol) Hydrogel Films Against Burn Wound Healing in Animal Model

Fabrication, Physical Characterizations, and In Vitro, In Vivo Evaluation of Ginger Extract-Loaded Gelatin/Poly(Vinyl Alcohol) Hydrogel Films Against Burn Wound Healing in Animal Model

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Shining Light on Chitosan: A Review on the Usage of Chitosan for Photonics and Nanomaterials Research

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