Synthesis and characterization of conducting polymer/alginate composite hydrogels: Effect of conducting polymer loading on the release behaviour of metformin drug

Mir, Aleena; Kumar, Amit; Riaz, Ufana

doi:10.1016/j.molliq.2022.121193

Cited by 12 publications

(15 citation statements)

References 41 publications

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“…The decrease in the viscosity was about 4 orders of magnitude, reaching a value of around 10 Pa·s at 10 s –1 . This suggested a relatively robust and rigid network structure that prevented gelatin chains from becoming entangled by sliding over one another by forming longer segments from multihelix structures. , The shear thinning behavior is governed by a number of factors, all of which are related to the structural reorganization of the fluid molecules due to flow. All hydrogels in the Newtonian region exhibited a smaller plateau.…”

Section: Resultsmentioning

confidence: 99%

“…The peak at 1630 cm –1 in PVDF/GL-B was indicative of the N–N stretching vibration, while the peaks at 1630, 1529, and 841 cm –1 were caused by deformation of the N–H vibration. The peak at 1079 cm –1 was attributed to the C–H stretching vibration, while the characteristic peaks for the β-phase of PVDF were observed at 510 and 841 cm –1 , respectively …”

Section: Resultsmentioning

confidence: 99%

“…Studies on the in vitro release of drug-loaded beads at pH 7.4 and pH 1.2 revealed different release characteristics. Our recent work on release of metformin drug using Na-alginate-based conducting polymer hydrogels showed that 99% drug release was attained for POPD/Na-ALG at 37 °C over a period of 12 h . Pourjalilia et al studied the creation of a novel gellan-based magnetic double network hydrogel nanocomposite (MDNH).…”

Section: Oscillatory Frequency Sweep Measurementsmentioning

confidence: 99%

“…The peak at 1079 cm −1 was attributed to the C−H stretching vibration, while the characteristic peaks for the β-phase of PVDF were observed at 510 and 841 cm −1 , respectively. 18 Scanning Electron Microscopy (SEM) Analysis. The SEM image of POPD/GL-B, Figure 1a, showed a swollen gel film with embedded agglomerates, while the SEM image of PNA/GL-B, Figure 1b, exhibited a sheet-like structure showing uniform distribution of PNA in the hydrogel.…”

Section: = × × Amount Of Drug Release Concentration Dissolution Bath ...mentioning

confidence: 99%

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Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Mir,

Fletcher,

Taylor

et al. 2024

ACS Omega

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The present work highlights the synthesis and characterization of conducting polymer (CP)-based composite hydrogels with gelatin (GL-B) for their application as drug delivery vehicles. The spectral, morphological, and rheological properties of the synthesized hydrogels were explored, and morphological studies confirmed formation of an intense interpenetrating network. Rheological measurements showed variation in the flow behavior with the type of conducting polymer. The hydrogels showed a slow drug release rate of about 10 h due to the presence of the conducting polymer. The release kinetics were fitted in various mathematical models and were best fit in first order for PNA-, POPD-, and PANI-based GL-B hydrogels, and the PVDF/GL-B hydrogel was best fit in the zero-order models. The drug release was found to follow the order: POPD/GL-B > PANI/GL-B > PVDF/GL-B.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Oscillatory Frequency Sweep Measurementsmentioning

confidence: 99%

Section: = × × Amount Of Drug Release Concentration Dissolution Bath ...mentioning

confidence: 99%

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Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Mir,

Fletcher,

Taylor

et al. 2024

ACS Omega

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“…Amoxicillin is an antibiotic-resistant drug that is used for the treatment of infections caused by bacteria such as bronchitis, pneumonia, infections associated with the ears, nose, and throat, urinary tract, skin, and infections in the skin. 23 The encapsulation efficiency (EE) of a drug is defined as the ratio of the entire amount of amoxicillin embedded in the synthesized hydrogel to the amount of the drug initially used. The required quantity of amoxicillin drug was added to the prepared hydrogel material, which results in absorption and swelling within the solution.…”

Section: Drugs Loading and Eementioning

confidence: 99%

Synthesis and characterization of poly (acrylamide‐co‐acrylic acid)/chitosan (derived from fish scales) for controlled release of amoxicillin drug

Sahoo,

Biswal

2024

Polymer Engineering & Sci

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Chitosan (CS) can be extracted from waste fish scales through a series of chemical processes, including demineralization, deproteinization, and deacetylation. The biomaterial poly (acrylamide [AM]‐co‐acrylic acid [AA])/CS is a unique superabsorbent material synthesized through the free radical graft copolymerization method by using AM, AA, and CS powder. During synthesis, ammonium persulfate is used as an initiator, and N, N′‐methylene bisacrylamide is used as a cross‐linker. Scanning electron microscopy and Fourier transform infrared spectroscopy have been studied to know about the morphology and structure of the synthesized superabsorbent materials. The water absorbency of the material continuously increases from day 1 to day 30. The thermogravimetric analysis (TGA) and derivative thermogravimetry (DTG) of the superabsorbent material show adequate thermal stability. The X‐ray diffraction (XRD) analysis indicates that the synthesized biomaterial is virtually amorphous in nature. The percentage of biodegradability increases with time. The encapsulation efficiency of amoxicillin drugs is around 70%, which indicates that the biomaterial is highly efficient for drug release applications. The synthesized novel biomaterial is a low‐cost, eco‐friendly, and thermally stable hydrogel that can be effectively used in drug release applications.Highlights Chitosan (CS)‐based hydrogels are highly pH‐sensitive towards drug release. The biodegradability and swelling behavior of the synthesized biomaterial were studied by adopting a suitable methodology. The novel material formed was characterized by using Fourier transform infrared spectroscopy, TGA, and Scanning electron microscopy. The encapsulation efficiency, kinetic study, and controlled drug release behavior of the amoxicillin drug were studied in solutions of simulated gastric fluid and phosphate‐buffered saline. The material developed in this study shows good performance in controlled drug delivery, and is therefore suitable for manufacturing medical devices used in drug delivery.

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Wireless, Programmable, and Refillable Hydrogel Bioelectronics for Enhanced Diabetic Wound Healing

Du,

Fan,

Zhang

et al. 2024

Advanced Science

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Diabetic wounds, characterized by complex pathogenesis and high infection rates, pose significant challenges in treatment due to prolonged recovery times and high recurrence rates, often leading to severe complications such as amputation and death. Traditional dry dressing treatments fail to address the unique microenvironment of diabetic wounds and tend to cause secondary damage due to frequent replacement. In this study, an electronic‐embedding, drug‐loading hydrogel bioelectronics is reported for accelerating diabetic wound healing using a combination of programmable pharmaceutical and electrostimulative approaches. Encapsulated in stretchable and biocompatible materials, this device is capable of multiple drug refilling and accelerated drug release modulated by on‐board electronics. In vivo experiments on diabetic model rats confirm the device's effectiveness in promoting wound healing. This innovative approach implies the potential for improving diabetic wound management using a combination of physical, material, and pharmaceutical interventions.

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Synthesis and characterization of conducting polymer/alginate composite hydrogels: Effect of conducting polymer loading on the release behaviour of metformin drug

Cited by 12 publications

References 41 publications

Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Sustained Release Studies of Metformin Hydrochloride Drug Using Conducting Polymer/Gelatin-Based Composite Hydrogels

Synthesis and characterization of poly (acrylamide‐co‐acrylic acid)/chitosan (derived from fish scales) for controlled release of amoxicillin drug

Wireless, Programmable, and Refillable Hydrogel Bioelectronics for Enhanced Diabetic Wound Healing

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