Synthesis and characterization of hydroxyapatite nanoparticles prepared by a high-gravity precipitation method

Han, Ping; Wang, Jie‐Xin; Lv, Shanshan; Wen, Jian; Chen, Jianfeng

doi:10.1016/j.ceramint.2015.07.067

Cited by 58 publications

(24 citation statements)

References 38 publications

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“…Therefore, alternative methods and simple techniques are employed to synthesize HA nanoparticles in industrial-scale with good quality, uniformity and perfect crystalline structure [11]. The various synthetic methods used to generate HA nanoparticles include microwave assisted, hydrothermal, sol-gel, microemulsion, freezing method, solvothermal, high-gravity precipitation and chemical precipitation methods [11][12][13][14][15][16][17]. However, in recent years, autoclave assisted hydrothermal method is also highly employed for the nanoparticle synthesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

Sundarabharathi¹,

Ponnamma

Parangusan

et al. 2019

SN Appl. Sci.

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Synthetic nano hydroxyapatites (HA) have been considered as potential biomaterials for bone tissue engineering applications because of its excellent biological properties. The present work deals with the synthesis of HA nanoparticles from different anion source materials via autoclave assisted hydrothermal method. All the prepared HA nanoparticles were characterized by X-ray diffraction (XRD), Fourier transformation infrared spectra, field emission scanning electron microscopy, energy dispersive spectra and high resolution transmission electron microscopy. The XRD patterns reveal the pure and hexagonal phase structure with smaller crystallite size for HA obtained from various calcium salt precursors. HA particles prepared from nitrate precursors show spherical morphology with 32 nm grain size whereas those derived from the acetate, chloride and egg shell precursors respectively show needle-like, irregular and oval morphology. The effect of different anions on the dielectric properties and alternating conductivity of HA is investigated, as a polarized surface can trigger biological reactions. For the particles obtained from nitrate, acetate, chloride and egg shell precursors respectively give dielectric constant (εʹ) values of 9.96, 13.22, 9.92 and 10.86 at 5 MHz. The εʹ and dielectric loss (εʹʹ) values for the HA nanoparticles decrease with increase in the applied frequency as well. The alternating current conductivity values confirm that the as-synthesized HA samples exhibit insulating behavior. In short this article provides the various applicability of HA particles in optoelectronics and drug delivery.

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Section: Introductionmentioning

confidence: 99%

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

Sundarabharathi¹,

Ponnamma

Parangusan

et al. 2019

SN Appl. Sci.

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“…There are various synthetic methods to generate the Eudoped and Sr-doped HA nanoparticles such as microwave assisted, 36 hydrothermal, 8,28 sol-gel, 37 microemulsion, 20 freezing method, 34 solvothermal, 38 and high-gravity precipitation method. 39 In recent years, sol-gel assisted precipitation method was used to generate all kinds of products due to its eminent advantages, which include high product purity, homogeneous compositions, and low synthesis temperature. 37,40,41 Herewith, we report the first attempt to synthesize Eu 31 /Sr 21 dual-substituted HA nanoparticles using sol-gel assisted precipitation method using a chelating agent ethylene diamine tetra acetic acid (EDTA).…”

Section: Introductionmentioning

confidence: 99%

In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu³⁺/Sr²⁺ dual‐doped nano‐hydroxyapatite for biomedical applications

et al. 2017

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In the present investigation, we have successfully synthesized luminescent Eu -doped and Eu /Sr codoped hydroxyapatite (HA) nanoparticles through sol-gel assisted precipitation method with the aim of developing novel biomaterials containing osteoblast mineral (Sr ) and luminescence activator (Eu ). The structure, morphology, thermal stability, and luminescence properties of the resultant spherical nanoparticles (50-100 nm diameters) were studied. Moreover, the in-vitro bioactivity of Eu Sr HA nanoparticles was investigated by immersing in the simulated body fluid for many weeks. The antimicrobial activity results against gram positive and gram negative bacterial stains, showed better resistivity for the Eu Sr HA among the other compositions. The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay of live/dead cells cultured with Eu /Sr -doped HA nanoparticles retained its normal morphology and did not show a significant impact on cell proliferation at various incubation days, which evidence for the material's superior biocompatible nature even at a higher concentration of 375 µg/mL. Thus, the incorporation of dual ions in HA nanoparticles with strong luminescence properties develops potential biomaterial for live cell imaging and in nanomedicine. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2191-2201, 2018.

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“…Figure displays the X‐ray diffraction patterns of the synthesized nHA. The diffraction peaks of synthesized nHA located at 25.84°, 31.76°, 39.73°, 46.67° and 49.57°, matched with those of the standard HA (JCPDS09–0432) . In addition, the broadening diffraction peaks of S50 and S100 showed that they were poorly crystalline and composed of small crystals.…”

Section: Resultsmentioning

confidence: 55%

The effect of hydroxyapatite nanoparticles on adipogenic differentiation of human mesenchymal stem cells

Yang

Huang

et al. 2018

J Biomedical Materials Res

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Due to its excellent biocompatibility, nanosized hydroxyapatite (nHA) has drawn much attention for various applications in biomedical fields. There are growing concerns about its biosecurity; however, little is known about its effects on adipogenesis. In the present study, nHA with three different sizes were synthesized, and the in vitro effects of nHA on cell proliferation and adipogenic differentiation of human mesenchymal stem cells (hMSCs) were investigated. The results clearly show that nHA does not affect the cell viability, the lipids droplets formation, triglyceride (TG) synthesis, and the expression of adipogenic marker genes/proteins of hMSCs at concentrations lower than 50 μg/mL. It is concluded that the adipogenic differentiation potential of hMSCs is not affected by nHA at noncytotoxic concentrations. These will provide a reference for the applications of nHA in biomedical fields. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1822-1831, 2018.

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Synthesis and characterization of hydroxyapatite nanoparticles prepared by a high-gravity precipitation method

Cited by 58 publications

References 38 publications

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu³⁺/Sr²⁺ dual‐doped nano‐hydroxyapatite for biomedical applications

The effect of hydroxyapatite nanoparticles on adipogenic differentiation of human mesenchymal stem cells

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Synthesis and characterization of hydroxyapatite nanoparticles prepared by a high-gravity precipitation method

Cited by 58 publications

References 38 publications

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu3+/Sr2+ dual‐doped nano‐hydroxyapatite for biomedical applications

The effect of hydroxyapatite nanoparticles on adipogenic differentiation of human mesenchymal stem cells

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In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu³⁺/Sr²⁺ dual‐doped nano‐hydroxyapatite for biomedical applications