Synthesis and characterization of ionic liquid microneedle patches with different carbon chain lengths for antibacterial application

Abstract

The prevention of bacterial infection is becoming more and more important in clinical medicine. Ionic liquids (ILs) can change the structure in an almost infinite way to actively antagonize pathogenic...

Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2

“…The skin healing at the puncture site after MN skin puncture was evaluated by experiments on isolated pig skin and in vivo rat skin. 35 The frozen pig skin was taken and soaked in physiological saline. After the pig skin was thawed, the surface water was removed with filter paper, then the skin was spread on the filter paper, with the cuticle facing outward, the microneedle was pressed vertically with a certain strength for 30 s, and the MNs were pulled out.…”

Advances of ionic liquid-based nanohybrids for biomedical applications

“…[28][29][30][31] This approach enables stable and continuous delivery of different drugs to specific parts to reduce pain and tissue damage, 32 and achieve hemostasis, antiinflammatory, antibacterial, tissue regeneration, etc. [33][34][35] For example, a MN patch containing salicylic acid (SA) and PILs was This journal is © The Royal Society of Chemistry 2023 prepared to treat acne infection (Fig. 3a).…”

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

“…[47] For example, choline and citric acid ([Ch][Cit]), choline and malioric acid ([Ch][Mal]), and choline and malic acid ([Ch][Mala]) did not irritate the skin of nude mice significantly at specific times. [48] Owing to their unique physicochemical and biological characteristics, ILs can be used as solubilizers, [49] skin penetration enhancers, [50] antibacterial agents, [51,52] and macromolecular stabilizers [53] for sparingly soluble drugs. [45,54] Deep eutectic solvents (DES) have properties similar to those of ILs, and are liquid at temperatures below 100 °C.…”