Synthesis and characterization of polypeptide containing liver‐targeting group

Abstract

Glycyrrhetinic acid, glycyrrhizic acid and bile acid were reported to be accumulated in liver. A series of novel liver-specific targeting polypeptides, poly(γ -benzyl-L-glutamate), were synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of γ -benzyl-L-glutamate (BLG-NCA) with amine-terminated compounds containing the above-mentioned liver-targeting group as an initiator. The molecular weights of the polypeptides were measured by gel permeation chromatography. The structures of these polypeptides and their initiators were confirmed by FTIR and 1 H-NMR spectroscopy. The results demonstrate that it is an efficient strategy to introduce a liver-targeting group into polymers via amine-terminated compounds containing glycyrrhetinic acid, glycyrrhizic acid and bile acid. The novel polymers have potential medical applications in targeted drug delivery.

Cytotoxicity of liver targeted drug-loaded alginate nanoparticles

“…Mao et al successfully prepared glycyrrhetinic acid surface-modified liposomes using the simple modified ethanol injection method [10] and confirmed there was a specific interaction between glycyrrhetinic acid surface-modified liposomes and rat liver parenchymal cells in vitro [11] . Poly(γ-benzyl-L-glutamate) containing a liver targeted group in the main chain and glycyrrhetinic acid modified chitosan nanoparticles were also prepared successfully in our previous study [12][13][14] .…”

Synthesis of organoarsenic, organoantimony, and organobismuth poly(ether esters) from reaction with glycyrrhetinic acid and their preliminary activity against pancreatic cancer cell lines

“…Wang and coworkers [61,62] synthesized new polymers by initially forming the monomer acrylglycyrrhetinic acid from reaction of GA with acryloyl chloride, and subsequent polymerization of this vinyl monomer. Yuan, Cha, and Du [63,64] synthesized a number of polypeptides from reaction with poly(gamma-benzyl-L-glutamate) which was formed from the ring-opening polymerization of the N-carboxyanhydride of gammabenzyl-L-glutamate.…”