Synthesis and characterization of superparamagnetic nanohybrid Fe₃O₄/NH₂‐Ag as an effective carrier for the delivery of acyclovir

Abstract

In this work, superparamagnetic nanohybrid material Fe 3 O 4 /NH 2 -Ag is uncovered as an attractive magnetic carrier for the controlled delivery of acyclovir (ACV). This magnetic nanoparticle was synthesized using the hydrothermal method. Then, the surface hydroxyl groups were extended by treating with tetraethyl orthosilicate (TEOS) and (3-aminopropyl) trimethoxysilane (APTMS). Finally, Ag nanoparticles were created on the surface of Fe 3 O 4 @SiO 2 -NH 2 nanospheres via reduction of Ag + ions. Decorated hybrid magnetite nanoparticles were then loaded with ACV as an active antiviral drug model. For this purpose, the amount of loading/release of the drug was investigated at different pH values. Structural characteristics of the functionalized nanomagnetic materials were investigated by Fourier transform-infrared spectroscopy, transmission electron microscopy, X-ray diffraction, thermogravimetric analysis and vibrating-sample magnetometry. The findings indicated that Fe 3 O 4 /NH 2 -Ag is highly efficient in loading and release of the selected model drug at pH 7.4.

Selective photocatalytic oxidation of aromatic alcohols to aldehydes with air by magnetic WO3ZnO/Fe3O4. In situ photochemical synthesis of 2-substituted benzimidazoles

“…The peak absorbed at 587 cm À1 belonged to the Fe-O vibration and the broad absorption peak at 3300-3500 cm À1 was due to the surface hydroxide ions. 47 The absorption band at 428 and 587 cm À1 were due to the ZnO moiety, whereas a weak and nearly wide band at 883 cm À1 would belong to WO 3 . 48,49 3.1.3.…”

Metal and Metal Oxides Nanoparticles and Nanosystems in Anticancer and Antiviral Theragnostic Agents

“…Additionally, Fe 3 O 4 /NH 2 -Ag was employed as a superparamagnetic nanohybrid carrier for acyclovir, whereby the material offered controlled delivery and sustained release behavior lasting for several hours. The kinetics of drug release depended on pH [163].…”

Delivery of anti-cancer and anti-depression doxepin drug by nickel oxide nanoparticles originated from the Cressa nudicaulis plant extract

“…7-9 Therefore, metal oxide nanoparticles have attracted much interest because of their extraordinary potential applications in drug delivery. [10][11][12][13] Currently, nickel oxide nanoparticles have played a signicant impact in medical treatments and clinical elds. NiO nanoparticles prompt oxidative pressure in cells that are generally caused by ion migration toward the nuclear cell membrane.…”