Synthesis and Characterization of Temperature-Sensitive Poly(<i>N</i>-isopropylacryamide) Hydrogel with Comonomer and Semi-IPN material

Yu, Yueqin; Liu, Yanping; Kong, Yanyan; Zhang, Erchi; Jia, Fuqiang; Li, Suhua

doi:10.1080/03602559.2012.671419

Cited by 24 publications

(4 citation statements)

References 17 publications

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“…The H n -PN m hydrogels exerted higher LCST compared with pure PNIPAm hydrogel, which was ascribed to the incorporation of hydrophilic HACC. LCST increased with the increase of hydrophilic polymer in the hydrogel network, which was because the excellent hydrophilicity of polymers hindered the dehydration of the hydrogel system . Noteworthily, the LCST of H n -PN m hydrogels is close to human temperature when the mass ratio of HACC/NIPAm is from 20/80 to 30/70.…”

Section: Resultsmentioning

confidence: 98%

“…LCST increased with the increase of hydrophilic polymer in the hydrogel network, which was because the excellent hydrophilicity of polymers hindered the dehydration of the hydrogel system. 51 Noteworthily, the LCST of H n -PN m hydrogels is close to human temperature when the mass ratio of HACC/NIPAm is from 20/80 to 30/70. According to the above test results of the swelling and temperature-sensitive properties of the H m -PN n hydrogels, the hydrogels have the potential as temperaturecontrolled drug release carriers.…”

Section: Swellingmentioning

confidence: 98%

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Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

et al. 2022

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Multifunctional hydrogel-based wound dressings have been explored for decades due to their huge potential in multifaceted medical intervention to wound healing. However, it is usually not easy to fabricate a single hydrogel with all of the desirable functions at one time. Herein, a bilayer model with an outer layer for hydrogel wound dressing was proposed. The inner layer (Hm-PNn) was a hybrid hydrogel prepared by N-isopropylacrylamide and chitosan-N-2-hydroxypropyl trimethylammonium chloride (HACC), and the outer layer (PVAo-PAmp) was prepared by polyvinyl alcohols and acrylamide. The two hydrogel layers of the bilayer model were covalently connected with excellent interfacial strength by photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization. The outer layer exposed to the ambient environment exhibited good stretchability and toughness, while the inner-layer hydrogel adhered to the skin exhibited excellent softness, antibacterial activity, thermoresponsivity, and biocompatibility. In particular, the inner layer of a hydrogel demonstrated excellent antibacterial capability toward both Staphylococcus aureus as Gram-positive bacteria and Escherichia coli as Gram-negative bacteria. Cell cytotoxicity showed that the cell viability of all Hm-PNn layer hydrogels exceeds 80%, confirming that the hydrogels bear excellent biocompatibility. In vivo experimental results indicated that the Hm-PNn/PVAo-PAmp bilayer hydrogel has a significant effect on the acceleration of wound healing, which was demonstrated in a full-thickness skin defect model showing improved collagen disposition and granulation tissue thickness. With these results, the established multifunctional bilayer hydrogel exhibits potential as an excellent wound dressing for wound healing applications, especially for open and infected traumas.

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Section: Resultsmentioning

confidence: 98%

Section: Swellingmentioning

confidence: 98%

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

et al. 2022

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“…One of the most useful methods to meet these requirements is to prepare semi-interpenetrating (semi-IPN) hydrogels by introducing a high hydrophilic linear polymer into the pNIPAM network. Semi-IPN hydrogels are usually synthesized by simultaneous polymerization of a monomer system with a cross-linking agent in the presence of natural polymer [ 18 , 25 , 26 , 27 ] or synthetic linear polymer chains [ 24 ], which will be physically entangled within the polymer network. The mechanical properties and response rate of the obtained hydrogels can thereby be improved.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of pH and Thermo Dual-Responsive Hydrogels with a Semi-IPN Structure Based on N-Isopropylacrylamide and Itaconamic Acid

et al. 2018

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A series of semi-interpenetrating polymer network (semi-IPN) hydrogels were synthesized and investigated in this study. Linear copolymer poly(N-isopropylacrylamide-co-itaconamic acid) p(NIPAM-co-IAM), which is formed by copolymerization of N-isopropylacrylamide (NIPAM) and itaconamic acid (IAM, 4-amino-2-ethylene-4-oxobutanoic acid), was introduced into a solution of NIPAM to form a series of pH and thermo dual-responsive p(NIPAM-co-IAM)/pNIPAM semi-IPN hydrogels by free radical polymerization. The structural, morphological, chemical, and physical properties of the linear copolymer and semi-IPN hydrogels were investigated. The semi-IPN hydrogel showed high thermal stability according to thermal gravimetric analyzer (TGA). Scanning electronic microscopy (SEM) images showed that the pore size was in the range of 119~297 µm and could be controlled by the addition ratio of the linear copolymer in the semi-IPN structure. The addition of linear copolymer increased the fracture strain from 57.5 ± 2.9% to 91.1 ± 4.9% depending on the added amount, while the compressive modulus decreased as the addition increased. Moreover, the pH and thermo dual-responsive properties were investigated using differential scanning calorimetry (DSC) and monitoring the swelling behavior of the hydrogels. In deionized (DI) water, the equilibrium swelling ratio of the hydrogels decreased as the temperature increased from 20 °C to 50 °C, while it varied in various pH buffer solutions. In addition, the swelling and deswelling rates of the hydrogels also significantly increased. The results indicate that the novel pH-thermo dual-responsive semi-IPN hydrogels were synthesized successfully and may be a potential material for biomedical, drug delivery, or absorption application.

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“…The thermosensitive nature of these hydrogels has been studied because this factor can be easily controlled and is applicable in vitro and in vivo conditions. Based upon its conformational changes, various PNIPAAm hydrogels have been studied as controlled optical switches, limiters and modulators (Yu et al 2012, Rejinold et al 2011. PNIPAAm hydrogels are well-known for their discontinuous phase separation near their lower critical solution temperature (LCST) and exhibit a sudden shrinking in volume at a temperature above LCST (Jaiswal et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a thermal responsive of poly(N-isopropylacrylamide)/chitosan/gelatin hydrogels

Baghaei¹,

Khorasani

2014

Biomaterials and Biomedical Engineering

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Synthesis of interpenetrating polymer network (IPN) of chitosan-gelatin (Cs-Ge) (as a primary network) and N-isopropylacrylamide (NIPAAm) monomer (as the secondary network) was carried out with different ratio. Its structure was characterized by FT-IR, which indicated that the IPN was formed. The memberanes were studied by swelling, weight loss with time. The interior morphology of the IPN hydrogels was revealed by scanning electron microscopy (SEM); the IPN hydrogels showed a interpenetrated network of NIPAAm/chitosan has layers with more minute stoma and canals compared to interpenetrated network of NIPAAm/gelatin. Lower critical solution temperature (LCST), equilibrium swelling ratio (ESR) and deswelling kinetics were measured. The DSC results noticed that LCST of IPN hydrogels with different ratio of Cs/Ge/PNIPAAm are around 33±2°C. The ESR obtained results showed that with a ratio of Cs/Ge/NIPAAm: 1/1/6, the swelling ratio increased drastically from room temperature to 36°C but with a ratio of Cs/Ge/PNIPAAm: 1/3/6, decrease significantly at the same condition. Therefore the hydrogels have been changed from a hydrophilic structure to a hydrophobic structure. Furthermore with an increase in temperature from room to the LCST, the ESR of IPN with higher concentration of (PNIPAAm) and (Ge) decreases but de-swelling kinetics of them are faster. Due to the suitable and different kinetics of de-swelling and the equilibrium swelling ratio (ESR) in various proportions, and because of the morphology inside the mass which confirms other tests, these hydrogels are very appropriate as a smart thermosensitive hydrogels with rapid response.

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Synthesis and Characterization of Temperature-Sensitive Poly(N-isopropylacryamide) Hydrogel with Comonomer and Semi-IPN material

Cited by 24 publications

References 17 publications

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

Synthesis and Characterization of pH and Thermo Dual-Responsive Hydrogels with a Semi-IPN Structure Based on N-Isopropylacrylamide and Itaconamic Acid

Preparation and characterization of a thermal responsive of poly(N-isopropylacrylamide)/chitosan/gelatin hydrogels

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