Synthesis and characterization of zinc(II) methacrylate monomer complex and adsorption properties of zinc(II) ion-imprinted polymer

Çıtlakoğlu, Meryem; Yolcu, Zuhal

doi:10.1016/j.ica.2023.121605

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…The C = O stretch vibrations include symmetric and antisymmetric stretch vibrations, which are slightly shifted compared with those of HPMA due to the formation of coordination bonds between -COOH and Gd 3+ [ 32 ]. The similar shift of C = O stretching vibration has also been observed in Gd complexes with -COOH groups [ 33 , 34 ].…”

Section: Resultssupporting

confidence: 75%

Kilogram scale facile synthesis and systematic characterization of a Gd-macrochelate as T1-weighted magnetic resonance imaging contrast agent

Shi,

Xiong,

Feng

et al. 2024

J Nanobiotechnol

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To overcome the problems of commercial magnetic resonance imaging (MRI) contrast agents (CAs) (i.e., small molecule Gd chelates), we have proposed a new concept of Gd macrochelates based on the coordination of Gd3+ and macromolecules, e.g., poly(acrylic acid) (PAA). To further decrease the r2/r1 ratio of the reported Gd macrochelates that is an important factor for T1 imaging, in this study, a superior macromolecule hydrolyzed polymaleic anhydride (HPMA) was found to coordinate Gd3+. The synthesis conditions were optimized and the generated Gd-HPMA macrochelate was systematically characterized. The obtained Gd-HPMA29 synthesized in a 100 L of reactor has a r1 value of 16.35 mM−1 s−1 and r2/r1 ratio of 2.05 at 7.0 T, a high Gd yield of 92.7% and a high product weight (1074 g), which demonstrates the feasibility of kilogram scale facile synthesis. After optimization of excipients and sterilization at a high temperature, the obtained Gd-HPMA30 formulation has a pH value of 7.97, osmolality of 691 mOsmol/kg water, density of 1.145 g/mL, and viscosity of 2.2 cP at 20 ℃ or 1.8 cP at 37 ℃, which meet all specifications and physicochemical criteria for clinical injections indicating the immense potential for clinical applications. Graphical Abstract

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Section: Resultssupporting

confidence: 75%

Kilogram scale facile synthesis and systematic characterization of a Gd-macrochelate as T1-weighted magnetic resonance imaging contrast agent

Shi,

Xiong,

Feng

et al. 2024

J Nanobiotechnol

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Dinuclear Pb(II) monomer complex: Synthesis, characterization, and application of Pb(II) ion-imprinted polymer as a selective potentiometric microsensor

Çıtlakoğlu

Yolcu

2023

Polyhedron

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The Multi-Challenges of the Multi-Ion-Imprinted Polymer Synthesis

Zepeda-Navarro,

Segoviano-Garfias,

Bivián-Castro

2024

Polymers

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Multi-ion-imprinted polymers (MIIPs) are materials with a wide range of applications mainly focused on environmental recovery, mining, technology, sensors, etc. MIIPs can incorporate ions such as heavy metals, transition metals, rare earth elements, radionuclides, and other types of ions. The chemical structures of MIIPs can be designed for different purposes and with certain morphologies, such as gels, crystals, or powders, and the surface area and porosity are also considered. All these properties provide the material with several desirable characteristics, like high selectivity, high specificity, adequate efficiency, good stability, the possibility of reusability, and strategy technology adaptation. In this review, we show the multitude of challenges of multi-ion imprinted polymer chemical synthesis based on the different and interesting methods reported previously.

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Synthesis and characterization of zinc(II) methacrylate monomer complex and adsorption properties of zinc(II) ion-imprinted polymer

Cited by 4 publications

References 39 publications

Kilogram scale facile synthesis and systematic characterization of a Gd-macrochelate as T1-weighted magnetic resonance imaging contrast agent

Kilogram scale facile synthesis and systematic characterization of a Gd-macrochelate as T1-weighted magnetic resonance imaging contrast agent

Dinuclear Pb(II) monomer complex: Synthesis, characterization, and application of Pb(II) ion-imprinted polymer as a selective potentiometric microsensor

The Multi-Challenges of the Multi-Ion-Imprinted Polymer Synthesis

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