Synthesis and Complexing Properties of 4-Arylthiazolyl-substituted Schiff Bases

Sadigova, S. E.; Магеррамов, А. М.; Allakhverdiev, M. A.; Alieva, R. A.; Chyragov, F. M.; Vekilova, T. M.

doi:10.1023/b:rugc.0000025156.16373.17

Cited by 9 publications

(7 citation statements)

References 3 publications

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“…(2.29 g, 0.01 mol) and thiourea (0.76 g, 0.01 mol) in ethanol (40 ml) was refluxed for 2 h. After addition of pyridine (5 ml) and continued reflux for 5 h, the solvent was removed under vacuum. The obtained Product 2a and 2b, respectively, were collected and crystallized; melting points were determined with authentic samples; yellow precipitation was formed; and the yield was 90 per cent (Sadigova et al, 2003).…”

Section: Synthesismentioning

confidence: 99%

Synthesis, application and antibacterial activity of new reactive dyes based on thiazole moiety

Mohamed

El-Megied

Bashandy

et al. 2018

PRT

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Purpose -This study aims to synthesise and characterise new reactive dyes based on thiazole derivatives which act as chromophoric moieties. These dyes were applied to cotton fabric, resulting in the dyed fabrics exhibiting good colour strength, light fastness and other fastness properties. The antibacterial activity of the dyed cotton fabric was evaluated against gram-negative and gram-positive bacteria. Design/methodology/approach -The dyes were synthesised in two steps. First, the coupling compound was formed by adding H-acid solution to cyanuric chloride in an ice bath at pH 5 then adding 4-aminobenzenesulphonic acid portion-wise at room temperature and at pH 6-7. Second, different diazonium salts 4-phenylthiazol-2-amine (2a) and 4-(4-methoxyphenyl) thiazol-2-amine (2b) were coupled with the coupling compound at pH 5. The resultant monochlorotriazine (MCT)-reactive dyes (6a, 6b) were formed. The synthesised dyes were applied onto cotton fabric under typical exhaust dyeing conditions and their dyeing properties were investigated. Findings -High antimicrobial activity, dye exhaustion and fixation yield on cotton fabric were recorded for each dye. All dyes showed high stability against washing, rubbing, perspiration and light fastness. Research limitations/implications -Dyeing of cotton fabric with these dyes which have higher fastness, higher exhaustion and higher antibacterial activity is considered one of the most important reactive dyes species. Practical implications -The preparation procedure showed the synthesis of the novel MCT-reactive dyes derived from thiazole derivatives followed by the application of these dyes on cotton fabrics. Social implications -Use of reactive dyes will bring a number of benefits to society including higher fastness and higher antibacterial activity so, and these dyes can be used for dyeing cotton. Originality/value -In this work, the new reactive dyes derived from thiazole derivatives were synthesised and their structures were confirmed by the analytical and spectral data. Such compounds are considered to be excellent reactive dyes with different colour shades and higher antibacterial activity.

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Section: Synthesismentioning

confidence: 99%

Synthesis, application and antibacterial activity of new reactive dyes based on thiazole moiety

Mohamed

El-Megied

Bashandy

et al. 2018

PRT

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“…Pyrrolomycin B, used as an antibiotic, represents an example of a bioactive pyrrole [7]. Such medicines as sulfathiazole, phthalylsulfathiazole and related compounds are commonly used in medical practice as well [8]. Besides, the antimicrobial profile of condensed thiophenes, particularly, their thieno [2,3-d]pyrimidin-4-one analogues is also well categorized in the literature [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Regioselective synthesis and antimicrobial studies of novel bridgehead nitrogen heterocycles containing the thienopyrimidinone skeleton

Gaber

Moussa

2011

Eur. J. Chem.

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KEYWORDSVersatile 2-(alkylthio)pyrimidine-type and 2-(phenacylamino)thiophene building blocks (4ad) and 16 were obtained based on an ortho functionalized thiophene derivative 1. A novel series of thieno[2,3-d]pyrimidin-4-one derivatives with annelated bridgehead nitrogen heterocycles was synthesized starting from precursors 4 and 16 through convenient methods. Cyclocondensation of 2-(phenacylthio)pyrimidinone derivative (4b) with sulfuric acid led to the tricyclic thiazole derivative 5. Initial hydrazinolysis of 3-(carbethoxymethyl)pyrimidinone derivative (4d) followed by nitrous acid deamination of the formed N-aminolactam (7) to obtain a N-protodeamino analogue 8a, which on further treatment with formaldehyde and piperidine yielded the respective Mannich-type base 8b. On the other hand, initial hydrazinolysis of 3-unsubstituted pyrimidinone derivative 4a and subsequent acetylation gave the condensed 3-methyltriazole derivative 12, whereas the condensed pyrrole derivative 19 was obtained by heterocyclization of 2-phenacylamine derivative 16 with malononitrile. All newly-obtained thienopyrimidinones with annelated bridgehead nitrogen were screened for their antimicrobial activity against strains of a representative panel of Gram-positive and Gram-negative bacteria as well as fungi together with reference drugs. The compounds under investigation displayed generally good in vitro antibacterial and antifungal activities, with compound 8b that has a N-piperidinylmethyl moiety showing essentially the highest inhibition in both assays. Despite promising antimicrobial activity of N-1-substituted imidazole derivative 8b, the corresponding N-1-unsubstituted analogue 8a displayed poor activity. The heteroannelation of a N-(piperidinylmethyl)imidazole or 3-methyltriazole moiety to the thienopyrimidinone scaffold could be considered as a potential strategy for the development of new therapeutic antimicrobial agents.Thienopyrimidinone Alkylation Cyclodehydration Hydrazinolysis Acetylation Antimicrobial activity

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“…In addition thiazole and benzothiazole were reported to be of commercial interest, for e.g. thiazole use as accelerators in rubber vulcanization, antioxidant, photochromics and dyestuffs [6]. Another use of ligand and its complexes as photo stabilizers of poly vinyl chloride products which increased the utilization of this polymer in buildings, mainly in exterior applications, such as window profiles, cladding structure and sidings [7][8][9], so because of these applications of the ligand and its complexes, we have been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Fe(II), Mn(II), Co(II), Hg(II) and Cr(III) Complexes of (Benzothiazol-2-Ylsulfanyl)-Acetic Acid Ligand

Yousif

Muaiad

Adil

2011

JNUS

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New metal complexes of the ligand (Benzothiazol-2-ylsulfanyl)-acetic acid with the metal ions Fe(II), Mn(II), Co(II), Hg(II) and Cr(III) were prepared in alcoholic medium.The prepared complexes were characterized by FTIR Spectroscopy, electronic spectroscopy, elemental analysis, 1 H NMR, 13 C NMR, magnetic susceptibility. From the spectral measurements, monomer structures for the complexes were proposed.

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Synthesis and Complexing Properties of 4-Arylthiazolyl-substituted Schiff Bases

Cited by 9 publications

References 3 publications

Synthesis, application and antibacterial activity of new reactive dyes based on thiazole moiety

Synthesis, application and antibacterial activity of new reactive dyes based on thiazole moiety

Regioselective synthesis and antimicrobial studies of novel bridgehead nitrogen heterocycles containing the thienopyrimidinone skeleton

Synthesis and Characterization of Fe(II), Mn(II), Co(II), Hg(II) and Cr(III) Complexes of (Benzothiazol-2-Ylsulfanyl)-Acetic Acid Ligand

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