Synthesis and Effect of Structure on Swelling Properties of Hydrogels Based on High Methylated Pectin and Acrylic Polymers

Kowalski, Grzegorz; Kijowska, Karolina; Witczak, Mariusz; Kuterasiński, Łukasz; Łukasiewicz, Marcin

doi:10.3390/polym11010114

Cited by 106 publications

(65 citation statements)

References 41 publications

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“…In this case, the release of active substances is on average 20% higher compared to the first hour for pH 3 and 7.4 for C-X and pH 3 for C-P NCaps. A possible explanation for these results may be the moderate rate of swelling of xanthan gum and pectin [20][21][22][23]. Compared to the release of the active substances alone, thymol was the best, then eugenol and then α-pinene was the worst in terms of release.…”

Section: Discussionmentioning

confidence: 99%

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Skaličková

Aulichova

Venusová

et al. 2020

IJMS

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It is generally believed that antibacterial essential oils have the potential to become one of the alternatives in preventing diarrheal diseases of monogastric animals. The disadvantage is their low efficiency per oral due to easy degradation during digestion in the stomach. This study compares the efficacy of chitosan, alginate-chitosan, guar gum-chitosan, xanthan gum-chitosan and pectin-chitosan nanocapsules to the synthesis of pH-responsive biopolymeric nanocapsule for Thymus vulgaris, Rosmarinus officinalis and Syzygium aromaticum essential oils. Using spectrophotometric approach and gas chromatography, release kinetics were determined in pH 3, 5.6 and 7.4. The growth rates of S. aureus and E. coli, as well as minimal inhibition concentration of essential oils were studied. The average encapsulation efficiency was 60%, and the loading efficiency was 70%. The size of the nanocapsules ranged from 100 nm to 500 nm. Results showed that chitosan-guar gum and chitosan-pectin nanocapsules released 30% of essential oils (EOs) at pH 3 and 80% at pH 7.4 during 3 h. Similar release kinetics were confirmed for thymol, eugenol and α-pinene. Minimal inhibition concentrations of Thymus vulgaris and Syzygium aromaticum essential oils ranged from 0.025 to 0.5%. Findings of this study suggest that the suitable pH-responsive nanocapsule for release, low toxicity and antibacterial activity is based on chitosan-guar gum structure.

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Section: Discussionmentioning

confidence: 99%

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Skaličková

Aulichova

Venusová

et al. 2020

IJMS

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“…Samples (0.5 g) of (α-M HG, α-M/HP-β-CD CX HG, and α-M/HP-β-CD PM HG) were immersed in phosphate buffer saline (PBS) solution pH 7.4 for 15, 30, and 60 min at room temperature. The swelling ratio was determined by the following Equation (1) [ 54 , 55 ].

where W d is the weight of the first HG, and W s is the weight of the swollen HG at a certain time.…”

Section: Methodsmentioning

confidence: 99%

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

et al. 2020

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α-Mangostin (α-M), one of the active compounds in Garcinia mangostana peel, has been effectively used in wound healing. However, its poor solubility in aqueous solution causes low bioavailability for skin ulcers, hindering its application in wound healing. The aim of this study was to improve the solubility of α-M through complex formation with 2-hydroxypropyl-β-cyclodextrin (α-M/HP-β-CD CX) and to evaluate the healing activity of the complex. The α-M/HP-β-CD CX was incorporated in a sodium carboxymethylcellulose hydrogel (α-M/HP-β-CD CX HG), and the in vivo healing activity was examined in mice. Evaluation of α-M/HP-β-CD CX HG, including organoleptic evaluation, homogeneity, pH, spreadability, swelling ratio, consistency, scanning electron microscopy (SEM), and in vitro drug release, was carried out. The complex formation of α-M/HP-β-CD CX was confirmed by FTIR and PXRD analysis. The solubility of the α-M/HP-β-CD CX in water linearly increased about 11.7-fold compared to α-M alone, and by 3.5-fold compared to the α-M/HP-β-CD physical mixture (α-M/HP-β-CD CX PM). The α-M/HP-β-CD CX HG was homogenous, the pH was found to be in the neutral range, the spread area was 5 cm, and the consistency was stable until 14 days. SEM analysis showed that α-M/HP-β-CD CX HG surged due to the porous structure of the HG. In addition, in vitro release of α-M from α-M/HP-β-CD CX HG was considerably increased compared to α-M/HP-β-CD PM HG and α-M HG. Notably, in vivo evaluation in mice showed that α-M/HP-β-CD CX HG significantly accelerated the wound healing ability compared to other HGs. Thus, α-M/HP-β-CD CX HG has potential as a new formulation of α-M for wound healing therapy.

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“…The more condensed nature and the excessive polymerization sites (PhOH) on KL could most likely have led to the formation of a highly cross-linked, denser polymeric network in KL-kaolin-acrylamide hydrogel, which is less permeable to solutions, and hence provides less accessible surface area for dye molecules to adsorb onto as compared to WLkaolin-acrylamide hydrogel. [49] Reusability: Although the hydrogels were still effective in dye removal, their adsorption rates were found to decrease with repeat use ( Table 6). The values of q e,calc and q e,exp were found to unexpectedly increase for WL-hydrogel, while they were found to decrease for KL-hydrogel and blank hydrogels after repeat use as expected.…”

Section: Lignin-kaolin-acrylamide Hydrogelmentioning

confidence: 99%

Willow Lignin Recovered from Hot‐Water Extraction for the Production of Hydrogels and Thermoplastic Blends

et al. 2020

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A blend of commercial willow cultivars (Salix spp.) was subjected to hydrothermal pretreatment: hot‐water extraction in a pilot plant 65‐ft3 digester. Lignin recovered from the autohydrolyzate (willow lignin, WL) was used to produce hydrogels and thermoplastic blends. Lignin‐kaolin‐acrylamide (WL 10.7 % w/w) and lignin‐poly(ethylene)glycol diglycidyl ether (WL 66.7 % w/w) hydrogels exhibited favorable adsorption and absorption properties, respectively. Dye adsorption kinetics, swelling capacities, fragrance emanation, and compression moduli were measured for the hydrogels, along with SEM characterization. Additionally, WL was esterified by acetylation (C2, WAc) and acylation with lauroyl chloride (C12, WFAE and WFAEH). The crude and esterified lignin samples were blended (1–12 % w/w) with polylactic acid (PLA) via lab‐scale melt extrusion to produce thermoplastic blends. The physicochemical properties of the blends were evaluated. They exhibited an increase in degradation temperature and UV absorbance with potential to hinder photodegradation of PLA and may be leveraged in packaging applications.

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Synthesis and Effect of Structure on Swelling Properties of Hydrogels Based on High Methylated Pectin and Acrylic Polymers

Cited by 106 publications

References 41 publications

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

Willow Lignin Recovered from Hot‐Water Extraction for the Production of Hydrogels and Thermoplastic Blends

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