Synthesis and electrochemical characterization of substituted indolizine carboxylates

Soare, Maria-Laura; Ungureanu, Eleonora‐Mihaela; Georgescu, Emilian; Bîrzan, Liviu

doi:10.2298/jsc120810117s

Cited by 4 publications

(2 citation statements)

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“…1,3-Diethyl 7-acetylindolizine-1,3-dicarboxylate ( 22 ) [61]. The reaction was performed with 12 (100 mg) and ethyl propiolate, following method D. The indolizine 22 was obtained in 12% yield (9 mg) as a white powder.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction

et al. 2016

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Abstract:The cycloaddition of pyridinium ylides with alkynes was investigated under mild conditions. A series of 13 pyridinium salts was prepared by alkylation of 4-substituted pyridines. Their reactivity with propiolic ester or amide in various reaction conditions (different temperatures, solvents, added bases) was studied, and 11 indolizines, with three points of structural variation, were, thus, isolated and characterized. The highest yields were obtained when electron-withdrawing groups were present on both the pyridinium ylide, generated in situ from the corresponding pyridinium salt, and the alkyne (X, Z = ester, amide, CN, carbonyl, etc.). Electron-withdrawing substituents, lowering the acid dissociation constant (pKa) of the pyridinium salts, allow the cycloaddition to proceed at pH 7.5 in aqueous buffers at room temperature.

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Section: Methodsmentioning

confidence: 99%

Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction

et al. 2016

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“…During the last two decades [15][16][17], new organic conducting polymers were synthesized and characterized, based on their electronic and electrochemical properties. Most of these new substances were obtained using various monomers, such as azulene, aniline, pyrrole and thiophene, as well as their derivatives [18][19][20][21][22].…”

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confidence: 99%

Stripping Voltammetry on a new Modified Glassy Carbon Electrode for Lead Content Determination in Soft Water

Vasile¹,

Arnold²,

Buica³

et al. 2018

Rev. Chim.

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This study develops a new electrochemical method for quantification of Pb in soft water using stripping voltammetry with a glassy carbon electrode modified with the functionalized azulene: (2E)-2-(azulen-1-ylmethylidene) hydrazine carbothioamide (L) as a complexing polymer film. The optimized steps of the proposed method consisted in experimental establishing of four parameters, namely: reduction time; reduction potential; complexation time; pH in acetate buffer and phosphate buffer. The modified electrodes were prepared in L solutions (1mM) in acetonitrile (CH3CN) containing tetra n-butyl ammonium perchlorate (0.1 M TBAP) as supporting electrolyte. The electrochemical method includes four main operations: 1) polymeric film formation by controlled potential electrolysis (CPE) at 1.7V using a charge of 1 mC; 2) film conditioning in 0.1 M buffer acetate solution using cyclic voltammetry; 3) 25 min complexation time in a standard solution prepared from lead nitrate (II) using as matrix ultrapure water or a real sample; 4) stripping by differential pulse voltammetry method (DPV) in acetate buffer at pH 4.0, after 120 s reduction time at a reduction potential of -1.0 V. Determination time for a single standard solution or real sample was around 45 min. Evaluation of the method performance parameters (linearity, working range, detection limit, quantification limit, repeatability, and recovery) was done. It confirms that the proposed method is suitable to detect and quantify lead content over 1.2 �g/L in soft water samples.

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Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: No Extra Heteroatom

Brandi¹,

Cicchi²,

Cordero³

2022

Comprehensive Heterocyclic Chemistry IV

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Synthesis and electrochemical characterization of substituted indolizine carboxylates

Cited by 4 publications

References 0 publications

Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction

Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic Coupling Reaction

Stripping Voltammetry on a new Modified Glassy Carbon Electrode for Lead Content Determination in Soft Water

Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: No Extra Heteroatom

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