Synthesis and Evaluation of Antiangiogenic and Anticancer Properties of Novel Oxadiazole Analogues

Abstract

Oxadiazole, a heterocyclic nucleus has attracted a wide attention of the chemist in search for the new therapeutic molecules. Out of its four possible isomers, 1, 3, 4-oxadiazole is biologically active, synthetically useful and widely exploited for various applications. Various biological activities are reported to be associated with 1, 3, 4-oxadiazoles. Encouraged by these reports the present study has been undertaken. The newly synthesized compounds were confirmed from IR, 1 H NMR and mass spectral data. All the synthesized compounds were subjected for anti angiogenesis as well as anticancer activity. Compounds 7b and 10d showed very good anti angiogenesis and anticancer activity compared to all other analogues in the series.