Synthesis and fibrinolytic activity of 2,3-substituted 4,5,6,7-tetrahydrothienopyridazines

Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-c]pyridazine Derivatives

“…5 On the other hand, thienopyridazines have also attracted attention because of their promising biological activities. 6,7 In connection with these facts, the utility of substituted thieno [2, 3-c]pyridazines as a synthon for the preparation of new substituted pyrido [2', 3' : 4, 5]thieno [2, 3-c]pyridazines and pyrimido [4', 5' : 4, 5]thieno- [2, 3-c]pyridazine is reported and an analysis of their biological activity is described. Amino ketone and aminocyano serve as good synthons for formation of a pyridine and pyrimidine rings.…”

Novel Synthesis of Thieno[2,3-c]Pyridazine and Pyrimido[4',5':4,5]thieno[2,3-c]pyridazine Derivatives

“…1,2 Also, thienopyridazine derivatives are important compounds due to their broad range of biological and pharmacological effects. [3][4][5] In addition, fused pyrimidines are found in a broad variety of pharmaceuticals, agrochemicals, and veterinary products. 6 In continuation of our work on pyridazine chemistry 7-9 , we reported the synthesis of some novel pyridazine, thieno [2,3-c]pyridazine and pyrimido [4 ,5 :4,5]thieno [2,3-c]pyridazine derivatives starting from the readily accessible 4-cyano-5,6-dimethylpyridazin-3(2H)-thione 3b.…”

Novel Syntheses of 5-Aminothieno[2,3-c]pyridazine, Pyrimido[4',5':4,5]thieno[2,3-c]pyridazine, Pyridazino[4',3':4,5]thieno-[3,2-d][1,2,3]triazine and Phthalazine Derivatives

“…A considerable number of pyridazine derivatives were found to have antibacterial, 1 analgesic, 2 antiinflammatory, 3 anticonvulsant, 4 acetyl-cholinesterase inhibitors, 5 aldose reductase inhibitor and antioxidant 6 properties. Some thienopyridazines have been reported to possess considerable antiasthmatic 7 and fibrinolytic 8 activities. In addition, 1,2,3triazine systems condensed with carbocycles or heterocycles are known to exhibit antiallergic activity.…”