Synthesis and Functionalization of Ordered Large‐Pore Mesoporous Silica Nanoparticles for Biomedical Applications

Chiu, Hsin-Yi; Leonhardt, Heinrich; Bein, Thomas

doi:10.1002/cite.201700021

Cited by 9 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such an approach was recently used to make mesoporous silica nano-size particles of silica with large pores. [35] These materials had both two dimensional hexagonal mesostructures that have pore sizes of roughly 7 nm as well as nano-particulates having a spherical morphology. The authors used a synthetic method involving delayed co-condensation in order to make bifunctional coreshell nano-sized mesoporous silicas that are site specific.…”

Section: Future Studiesmentioning

confidence: 99%

“…As such these materials are carriers of nano-size mesoporous materials that can be used to deliver different species to cells. [35] Combinations of methods will also likely happen as will miniaturization of some instrumentation. These combinations may be important in characterization studies as well as in syntheses or in catalytic reactions.…”

Section: Future Studiesmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Recent Developments of Mesoporous Materials

Suib

2017

The Chemical Record

107

View full text Add to dashboard Cite

This personal account concerns novel recent discoveries in the area of mesoporous materials. Most of the papers discussed have been published within the last two to three years. A major emphasis of most of these papers is the synthesis of unique mesoporous materials by a variety of synthetic methods. Many of these articles focus on the control of the pore sizes and shapes of mesoporous materials. Synthetic methods of various types have been used for such control of porosity including soft templating, hard templating, nano-casting, electrochemical methods, surface functionalization, and trapping of species in pores. The types of mesoporous materials range from carbon materials, metal oxides, metal sulfides, metal nitrides, carbonitriles, metal organic frameworks (MOFs), and composite materials. The vast majority of recent publications have centered around biological applications with a majority dealing with drug delivery systems. Several other bio-based articles on mesoporous systems concern biomass conversion and biofuels, magnetic resonance imaging (MRI) studies, ultrasound therapy, enzyme immobilization, antigen targeting, biodegradation of inorganic materials, applications for improved digestion, and antitumor activity. Numerous nonbiological applications of mesoporous materials have been pursued recently. Some specific examples are photocatalysis, photo-electrocatalysis, lithium ion batteries, heterogeneous catalysis, extraction of metals, extraction of lanthanide and actinide species, chiral separations and catalysis, capturing and the mode of binding of carbon dioxide (CO ), optical devices, and magneto-optical devices. Of this latter class of applications, heterogeneous catalysis is predominant. Some of the types of catalytic reactions being pursued include hydrogen generation, selective oxidations, aminolysis, Suzuki coupling and other coupling reactions, oxygen reduction reactions (ORR), oxygen evolution reactions (OER), and bifunctional catalysis. For perspective, there have been over 40,000 articles on mesoporous materials published in the last 4 years and about 1388 reviews. By no means is this personal account thorough or all inclusive. One objective has been to choose a variety of articles of different types to obtain a flavor of the breadth of diversity involved in the area of mesoporous materials.

show abstract

Section: Future Studiesmentioning

confidence: 99%

Section: Future Studiesmentioning

confidence: 99%

A Review of Recent Developments of Mesoporous Materials

Suib

2017

The Chemical Record

107

View full text Add to dashboard Cite

show abstract

“…There are many methods to realize CMSN with large mesopores, including prolonging the length of the template agent chain, changing templates, adjusting pH of the synthesized system and adding additives. For instance, the mesopores can be enlarged to 10 nm using designed surfactant [10,11,12]. It was reported that mesopores in the range of 3.8 to 20 nm can be regulated by controlling systemic pH.…”

Section: Introductionmentioning

confidence: 99%

Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect

et al. 2019

View full text Add to dashboard Cite

Large mesopores of chiral silica nanoparticles applied as drug carrier are worth studying. In this study, chiral mesoporous silica nanoparticles (CMSN) and enlarged chiral mesoporous silica nanoparticles (E-CMSN) with a particle size from 200 to 300 nm were synthesized. Fourier transform infrared spectrometer (FTIR), circular dichroism spectrum, scanning electron microscopy (SEM), transmission electron microscope (TEM), and nitrogen adsorption/desorption measurement were adopted to explore their characteristics. The results showed that the surface area, pore volume, and pore diameter of E-CMSN were higher than those of CMSN due to enlarged mesopores. Poorly water-soluble drug nimesulide (NMS) was taken as the model drug and loaded into carriers using adsorption method. After NMS was loaded into CMSN and E-CMSN, most crystalline NMS converted to amorphous phase and E-CMSN was superior. The anti-inflammatory pharmacodynamics and in vivo pharmacokinetics results were consistent with the wetting property and in vitro drug dissolution results, verifying that NMS/E-CMSN exhibited superior NMS delivery system based on its higher oral relative bioavailability and anti-inflammatory effect because its enlarge mesopores contributed to load and release more amorphous NMS. The minor variations in the synthesis process contributed to optimize the chiral nano-silica drug delivery system.

show abstract

“…MSP are chemically synthesized either in the form of ordered or unordered particles varying in their internal arrangement involving the pores and structures [16,17]. Several ingredients though engaged in the synthesis, main components of MSP system consists of a silica precursor and structure directing surfactants.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Particles for Dermal Drug Delivery: A Review

2018

View full text Add to dashboard Cite

Mesoporous silica particles (MSP) have been reported to be applicable in diverse situations pertaining to the delivery of several drug molecules. MSP have established themselves in treating diseases with oral, dermal and parenteral modes of administration. Recently, dermal delivery using MSP have gained a considerable amount of interest owing to the increase in drug stability, permeation and ease of functionalization. MSP, in general, have a very high capability of delivering actives ranging from small molecules like drugs and amino acids to larger peptides, vaccines and antibodies. The applicability of MSP in achieving desired cosmetic and health-related outcomes depends on the careful tuning of their pore size, surface area, shape and overall physicochemical properties. This review provides comprehensive details of the recent developments in the fabrication of MSP, their characteristic features and, applications in dermal drug delivery. Studies on establishing the safety profile of MSP have also been summarized in the review.

show abstract

Synthesis and Functionalization of Ordered Large‐Pore Mesoporous Silica Nanoparticles for Biomedical Applications

Cited by 9 publications

References 34 publications

A Review of Recent Developments of Mesoporous Materials

A Review of Recent Developments of Mesoporous Materials

Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect

Mesoporous Silica Particles for Dermal Drug Delivery: A Review

Contact Info

Product

Resources

About