Synthesis and hypoglycemic activity of 3-aryl(or pyridyl)-5-alkyl(or aryl)amino-1,3,4-thiadiazoles and some sulfonylurea derivatives of 4H-1,2,4-triazoles

Abstract

When II was added to as-dichlorobis(ethylenediamine)cobalt(3 + ) chloride in MeOH, [7-amino-S-(aminomethyl)-l,

Synthesis and Antimicrobial Activity of Modified 1,3,4-Oxadiazoles and Their Sugar Derivatives

“…Among the five-membered nitrogen heterocycles, the 1,3,4-oxadiazoles are associated with broad spectrum of biological activities ) Zareen et al, 2004;El-Azzouny at al., 2003;Loetchutinat et al, 2003). Their derivatives have been known to possess antibacterial (Ates et al, 1997), antimicrobial (Rahman and Farghaly 2004), insecticidal (Li et al, 2003), herbicidal, fungicidal (Zou et al, 2002), anti-inflammatory (Palaska et al, 2002), hypoglycaemic (Mhasalkar et al, 1971) characteristics, antiviral (El-Emam et al, 2004, and anti-tumour activities (Liszkiewicz et al, 2003). On the other hand, the acyclic C-nucleoside analogues possess a wide range of biological properties, including antibiotic, antiviral, and anti-tumour activities (Holy, 1987;Remy and Secrist, 1985;Larson et al, 1983;El Ashry and El Kilany, 1996;1998;Chu and Cutler, 1986;Markar and Keseru, 1997;Franchetti et al, 1997;Hammerschmidt et al, 1997).…”

Exploring The Synthesis of 1,2,4-Triazole Derivatives: A Comprehensive Review

“…The first scientist who gives the name Triazole is Bladin in 1885 [1]. Triazole widely different activities for instance antiinflammatory [2][3][4], anticancer [5,6], antibacterial [7][8][9], antifungal [10,11], antitubercular [12,13], antiviral [14,15], anti-convulsant [10,16,17], antihelmintic [18], antinociceptive [19][20][21], analgesic [22], anti-corrosive [23], antioxidant [24][25][26][27], hypoglycemic [28], urease & lipase inhibitors [29], anti-proliferative diuretic, sedative, antimigraine, anti-HIV and muscle relaxant [30].…”

Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety

“…1, 2, 4-triazoles has received substantial attention due to their effective biological importance like anticancer (1), antibacterial (2,3), anticonvulsant (4), antiinflammatory, analgesic (5), antifungal (6,7), antidepressant (8), antitubercular (9), antimalarial (10) and hypoglycemic (11) activities. The isoxazole nucleus is well known for its medicinal importance and a number of related compounds are known to exhibit antifungal (12), antimicrobial (13), anticancer (14), analgesic, antiinflammatory (15), antituberculine (16), antiviral (17), antipsychotic (18), and hypoglycemic (19) activities.…”