Synthesis and In Vitro Evaluation of Caffeoylquinic Acid Derivatives as Potential Hypolipidemic Agents

Tian, Yu; Cao, Xiaoxue; Shang, Hai; Wu, Chongming; Zhang, Xi; Guo, Peng; Zhang, Xiaopo; Xu, Xudong

doi:10.3390/molecules24050964

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Triglycerides (TGs) play a vital role in coronary heart disease (CHD) and atherosclerosis. In 2019, a series of CQA derivatives were designed and synthesized (figure not shown) . At a concentration of 10 μM, compounds containing a propargyl group displayed a potent lipid-lowering effect, with more potential than the positive control, simvastatin, and 5-CQA ( 9 ).…”

Section: Biological Activities Of Natural Cqasmentioning

confidence: 99%

“…In 2019, a series of CQA derivatives were designed and synthesized (figure not shown). 150 At a concentration of 10 μM, compounds containing a propargyl group displayed a potent lipidlowering effect, with more potential than the positive control, simvastatin, and 5-CQA (9). The mechanism may be through reducing the levels of TGs in HepG2 liver cells.…”

Section: Biological Activities Of Natural Cqasmentioning

confidence: 99%

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Current Advances in Naturally Occurring Caffeoylquinic Acids: Structure, Bioactivity, and Synthesis

Liu

Zhang

et al. 2020

J. Agric. Food Chem.

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Caffeoylquinic acids (CQAs) are a broad class of secondary metabolites that have been found in edible and medicinal plants from various families. It has been 100 years since the discovery of chlorogenic acid in 1920. In recent years, a number of naturally derived CQAs have been isolated and structurally elucidated. Accumulated evidence demonstrate that CQAs have a wide range of biological activities, such as antioxidation, antibacterial, antiparasitic, neuroprotective, anti-inflammatory, anticancer, antiviral, and antidiabetic effects. Up to date, some meaningful progresses on the biosynthesis and total synthesis of CQAs have also been made. Therefore, it is necessary to comprehensively summarize the structure, biological activity, biosynthesis, and chemical synthesis of CQAs. This review provides extensive coverage of naturally occurring CQAs discovered from 1990 until 2020. Modern isolation techniques, chemical data (including structure, biosynthesis, and total synthesis), and bioactivity are summarized. This would be helpful for further research of CQAs as potential pharmaceutical agents.

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Section: Biological Activities Of Natural Cqasmentioning

confidence: 99%

Section: Biological Activities Of Natural Cqasmentioning

confidence: 99%