Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery

Kafedjiiski, Krum; Jetti, Ram K. R.; Föger, Florian; Hoyer, Herbert; Werle, Martin; Hoffer, Martin; Bernkop‐Schnürch, Andreas

doi:10.1016/j.ijpharm.2007.04.019

Cited by 121 publications

(64 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 Further, the thermogram for chondroitin sulfate shows an exothermic peak at 231°C, while hyaluronic acid shows two exothermic peaks at 227°C and 243°C, respectively, which are attributable to degradation of these polysaccharides. 24, 47 The methylprednisolone thermogram shows an endothermic transition at 220°C and an endothermic melting peak at 238°C ( Figure 4A). 48 However, differential scanning calorimetry curves for all the microparticle preparations show an endothermic peak typical of albumin denaturation, as well as an exothermic peak at 221°C possibly due to degradation or decomposition of the component resulting from the formulation excipients molecular crossing-over ( Figure 4B).…”

Section: Tablementioning

confidence: 99%

“…23 Hyaluronic acid and chondroitin sulfate are polysaccharides found in the synovial fluid, extracellular matrix, and connective tissue, and have an important role in articular homeostasis. 24,25 In addition, they have anti-inflammatory and anticatabolic properties that attenuate production of inflammatory mediators by chondrocytes, 26 as well as having an analgesic action in arthritic joints. 27 It has also been demonstrated that hyaluronic acid and chondroitin sulfate reduce friction and strain on the articular cartilage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

Tobar-Grande¹,

Godoy²,

Bustos³

et al. 2013

IJN

View full text Add to dashboard Cite

Abstract:In this work, microparticles were prepared by spray-drying using albumin, chondroitin sulfate, and hyaluronic acid as excipients to create a controlled-release methylprednisolone system for use in inflammatory disorders such as arthritis. Scanning electron microscopy demonstrated that these microparticles were almost spherical, with development of surface wrinkling as the methylprednisolone load in the formulation was increased. The methylprednisolone load also had a direct influence on the mean diameter and zeta potential of the microparticles. Interactions between formulation excipients and the active drug were evaluated by x-ray diffraction, differential scanning calorimetry, and thermal gravimetric analysis, showing limited amounts of methylprednisolone in a crystalline state in the loaded microparticles. The encapsulation efficiency of methylprednisolone was approximately 89% in all formulations. The rate of methylprednisolone release from the microparticles depended on the initial drug load in the formulation. In vitro cytotoxic evaluation using THP-1 cells showed that none of the formulations prepared triggered an inflammatory response on release of interleukin-1β, nor did they affect cellular viability, except for the 9.1% methylprednisolone formulation, which was the maximum test concentration used. The microparticles developed in this study have characteristics amenable to a therapeutic role in inflammatory pathology, such as arthritis.

show abstract

Section: Tablementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

Tobar-Grande¹,

Godoy²,

Bustos³

et al. 2013

IJN

View full text Add to dashboard Cite

show abstract

“…HA is also known to have pivotal roles in various biological functions, such as stabilizing and organizing the ECM, regulating cell adhesion, motility, mediating cell proliferation and differentiation (Kafedjiiski et al, 2007;Guechot et al, 2008). Moreover, HA receptors such as CD44 and RHAMM are abundantly presented in tumor cells (Huang et al, 2007;Afify et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Positive hyaluronan/PEI/DNA complexes as a target-specific intracellular delivery to malignant breast cancer

Sun

Cao

et al. 2009

Drug Delivery

View full text Add to dashboard Cite

“…Many polymeric materials have been investigated since the body's natural processes can easily handle the by-products resulting fro m their degradation, with the by-products being easily excreted in the urine. Natural poly mers such as polysaccharides [36][37][38][39][40], chitosan [41][42][43][44][45][46], hyaluronic based derivatives [47][48][49][50] and protein based materials such as fibrin gel [51,52] and collagen [53][54][55][56], have all produced favourable outcomes in a number of tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant

Poinern¹,

Brundavanam²,

Fawcett³

2013

AJBE

283

View full text Add to dashboard Cite

Magnesium and magnesium based alloys are lightweight metallic materials that are extremely biocompatib le and have similar mechanical properties to natural bone. These materials have the potential to function as an osteoconductive and biodegradable substitute in load bearing applicat ions in the field of hard t issue engineering. However, the effects of corrosion and degradation in the physiological environ ment of the body has prevented their wide spread applicat ion to date. The aim o f this review is to examine the properties, chemical stability, degradation in situ and methods of improving the corrosion resistance of magnesium and its alloys for potential application in the orthopaedic field. To be an effective imp lant, the surface and sub-surface properties of the material needs to be carefully selected so that the degradation kinetics of the implant can be efficiently controlled. Several surface modification techniques are presented and their effectiveness in reducing the corrosion rate and methods of controlling the degradation period are discussed. Ideally, balancing the gradual loss of material and mechanical strength during degradation, with the increasing strength and stability of the newly forming bone tissue is the ultimate goal. If this goal can be achieved, then orthopaedic implants manufactured fro m magnesium based alloys have the potential to deliver successful clinical outcomes without the need for revision surgery.

show abstract

Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery

Cited by 121 publications

References 29 publications

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

Positive hyaluronan/PEI/DNA complexes as a target-specific intracellular delivery to malignant breast cancer

Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant

Contact Info

Product

Resources

About