Synthesis and insecticidal activity of N-cyano 2-(substituted amino) ethyl methyl sulfoximine derivatives

Abstract

The N-cyano 2-(substituted amino)ethyl methyl sulfoximine derivatives are a new chemical family of neonicotinoids. Nine alkyl sulfoximine derivatives were designed and synthesized. The synthesized compounds were identified by 1 H NMR, 13 C NMR, IR, and elemental analysis. The preliminary bioassays indicated that some of them showed moderate insecticidal activities against Myzus persicae. The relationship between structure and biological activity was also discussed.

Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

“…2 Furthermore, some cyanamides are known to have biological activities. For example, N-cyano 2-(substituted amino)ethyl methyl sulfoximines 3 and imicyafos 4 (Figure 1) have been tested for their insecticidal activity against peach aphids and nematodes, respectively. In addition, some cyanamides that inhibit Rhizoctonia solani 5 and type IV phosphodiesterase (PDE4) 6 have been identified in medicinal chemistry.…”