Synthesis and Insecticidal Activity of Some 1,3,4‐Oxadiazoles Derived from 2‐Chloropyridine‐5‐acetic Acid.

Holla, B. Shivarama; Prasanna, C. S.; Poojary, Boja; Rao, K. Srinivasa; Shridhara, K.; Bhat, U. Ganesha

doi:10.1002/chin.200432162

Cited by 7 publications

(7 citation statements)

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“…[11,[21][22][23][24][25][26] Pyridine derivatives have shown potent pharmacological properties, such as antimicrobial, fungicidal, insecticidal, and pesticidal properties. [27][28][29] Aminopyridines are considered essential members of a family of monoamine and diaminopyridine derivatives, and their main mechanism and work of action depend on the blockade dosages of voltage-gated potassium channels. In this manner, they are adequately utilized as examination instruments in describing potassium channel subtypes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

Abdel‐Rahman

Basha

Al–Farhan

et al. 2021

Applied Organom Chemis

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In this study, five novel complexes for Co(II), Ni(II), VO(II), Cr(III), and La(III) ions were synthesized from a tridentate NNO monobasic chelating Schiff base ligand, (Z)-2-((pyridin-2-ylimino)methyl)phenol (HL). Spectral and analytical tools were applied to elucidate the structural compositions of the new compounds. Then, geometry optimization was conducted for all the syntheses by the Gaussian 09 program via the density functional theory method to obtain optimal structures and the most essential parameters. Moreover, the biochemical behaviors of all the syntheses were explored based on the reactivity, which was tested against various cancer cell lines (HepG-2, MCF-7, and HCT-116). The complexes exhibited an interestingly antiproliferative potential against human cancer cell lines, and the cytotoxicities of the new complexes were arranged to follow the order: VOL > CrL > NiL > LaL > CoL > HL. The antioxidant behaviors of the complexes were studied using the DPPH assay, and VOL showed the maximum antioxidant activity, followed by LaL. The antibacterial activities of the HL ligand and its complexes were studied. Moreover, the binding nature of the complexes with calf thymus DNA (CT-DNA) was investigated based on the spectrophotometric absorption titration, viscosity, and gel electrophoresis methods. The binding ability of the complexes with CT-DNA was proposed to be just intercalation or replacement mode. The intrinsic binding constant K b was calculated and arranged based on the following order: VOL (5.2 Â 10 5 ) > CrL (3.6 Â 10 5 ) > NiL (3.3 Â 10 5 ) > LaL (3.0 Â 10 5 ) > CoL (1.12 Â 10 5 ) mol À1 dm À3 . Docking investigations were performed using the receptors of COVID-19's main protease viral protein (PDB ID: 6LU7) and Escherichia coli (gram [-ve] bacteria [PDB ID: 1fj4]).

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

Abdel‐Rahman

Basha

Al–Farhan

et al. 2021

Applied Organom Chemis

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“…1,3,4-Oxadiazole derivatives constitute an important class of heterocycles possessing diverse biological activities like antibacterial [1][2][3][4], fungitoxic [5,6], insecticidal [7], herbicidal [8], anticancer [9], anti-inflammatory [10] etc. Further, [5-(aryl)-1,3,4-thiadiazole-2-ylthio]acetates and propionates have been found to possess antimycobacterial activity [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Syntheses and antibacterial studies of some 2-[5-(Aryl)-[1,3,4]oxadiazole-2-ylsulfanyl] alkanoic Acids

Jain¹,

Pathak

Mishra

et al. 2009

JICS

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Some new 2-[5-(aryl)-[1,3,4]oxadiazole-2-ylsulfanyl]alkanoic acids were synthesized and studied for their antibacterial activity. These compounds were prepared from aromatic carboxylic acid hydrazides. Aromatic carboxylic acid hydrazides 1 on refluxing with carbon disulfide and methanolic potassium hydroxide and then on subsequent acidification with hydrochloric acid furnish 5-aryl-1,3,4-oxadiazole-2-thiones 2. 2-Chloro alkanoic acids react with 2 in alkaline media and on acidification yield the title compounds 3. These compounds were characterised by CHN analyses, IR, mass and 1 H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined.

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“…The thiazole derivatives are widely used in the field of medicine, industry and in agriculture. The derivatives of thiazole have been reported as fungicides [2][3] , Pesticides 4 , insectides 5 , antibacterial [6][7] , anti-inflammatory 8 , anticonvulsant 9 , antitubercular 10 , antiviral 11 , and anticancer …”

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confidence: 99%

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2015

IJPSR

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ABSTRACT:The condensation of 2-imino-5 substituted benzylidene-4-thiazolidinone (1) with thiourea (2) in presence of glacial acetic acid to gives 2-substituted imino-7-substituted phenyl-3,7-dihydro-2H-[1,3] thiazolo [5,4-e]-thiazin-5-amine (3). The antifungal activities of the compounds (3a-h) were tested against A.niger and A. flavus. The growth of both fungi A. niger and A. flavus are inhibited to some extent by all the synthesized compounds Hence all are antifungal agents.

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Synthesis and Insecticidal Activity of Some 1,3,4‐Oxadiazoles Derived from 2‐Chloropyridine‐5‐acetic Acid.

Abstract: The insecticidal activity of newly synthesized substances (IV) containing both 2-chloro-5-methyl pyridine and 1,3,4-oxadiazole moieties is studied. -(HOLLA*, B. S.; PRASANNA, C. S.; POOJARY, B.; RAO, K. S.; SHRIDHARA, K.; BHAT, U. G.; Indian J.

Cited by 7 publications

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Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

Syntheses and antibacterial studies of some 2-[5-(Aryl)-[1,3,4]oxadiazole-2-ylsulfanyl] alkanoic Acids

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