Synthesis and optimization of a new calcium phosphate ceramic using a design of experiments

Jabri, Mohammed; Mejdoubi, E.; Gadi, M. El; Hammouti, B.

doi:10.1007/s11164-012-0587-9

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…Nowadays, using of different nanomaterials such as Ag, CuO, and TiO2 are used in preparing new mouthwashes with various functionality (14)(15)(16). Amorphous calcium phosphate (ACP) is known as one of the promising substances that can release calcium and phosphate for the prevention and treatment of decalcification (17,18). Recently, materials that contain ACP nanoparticles (ACP-NPs) have been especially attractive on the account of their excellent performance, considering how their properties are better than ACP in bulk form due to their specific area.…”

Section: Introductionmentioning

confidence: 99%

Amorphous calcium phosphate nanoparticles-based mouthwash: preparation, characterization, and anti-bacterial effects

Pakravanan

Roknabadi

Farzanegan

et al. 2019

Green Chemistry Letters and Reviews

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The objective of this study is to prepare a novel mouthwash that contains Amorphous Calcium Phosphate nanoparticles (ACP-NPs) in a chitosan aqueous solution in order to prevent and treat the existing enamel decalcification around the brackets and gingivitis. ACP-NPs have been synthesized via a co-precipitation technique from the solution of ammonium hydrogen phosphate and calcium chloride, as well as the addition of sodium hydroxide for the adjustment of pH ∼ 8. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), Energy dispersive X-ray spectroscopy (EDX), and the Barrett-Joyner-Halenda (BJH) desorption have been performed on the samples. The ACP-NPs seemed to contain an initial particle size of less than 40 nm and the Ca/P ratio of 1.14. We have applied chitosan since it can function as the stabilizer, antibacterial, and anti-inflammatory and thus, prevent plaque, bad breath, and decrease gingivitis. Agar dilution has been utilized to assess the antibacterial or effectiveness of the prepared mouthwash. This particular mouthwash can be considered smart since it has the ability to increase the ion release at a carcinogenic pH 4, which is the significant timing when these ions are mostly needed and required to inhibit the caries.

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