Synthesis and orientational pharmacological study of hydrogenated isoindoles

4,7-Dihydro-, 4,5,6,7-tetrahydro-, and octahydroisoindoles (and methanoisoindoles). (Review)

“…We made a systematic pharmacological study of the biological characteristics of isoindoles [43,[59][60][61][62][63][64][65][66][67]69]. As a result of the tests substances with neurotropic, hypotensive, radioprotective, diuretic, bactericidal, antihelminthic, and fungicidal characteristics were found.…”

“…The recyclization of diene condensation adducts based on methoxydihydrofurans with primary amines has found use in the synthesis of biologically active compounds having specific characteristics [43,[59][60][61][62][63][64][65][66][67][68][69] and also in the production of the 4,5,6,7-tetrahydroisoindole fragments of porphyrins [70].…”

“…Thus, the hydrogenation of 2-methyl-1,3-diphenylisoindole at Raney nickel in dioxane gives the octahydro derivative 78. As a result of the hydrogenation (at initial hydrogen pressure 10 MPa) of 4,5,6,7-tetrahydroisoindoles 43, synthesized by the methods in [40][41][42], the octahydroisoindoles 81-84 were obtained and used for pharmacological investigation [65,115] cat.…”