Synthesis and Pharmacological Evaluation: Antimicrobial, Anti-Inflammatory, Analgesic, Ulcerogenic Properties of Several Bis-Heterocyclic Derivatives

Abstract

In Medicinal chemistry, heterocyclic derivatives contributed the largest classical division of organic chemistry. Thiadiazole compounds have been known for many biological activities such as hypoglycemic, anticancer, anti-inflammatory, anti-asthmatic, antihypertensive etc. On this research, several 1,1-bis [2-{2-(5-(arylidene)imino-1,3,4-thiadiazol-2-yl) methyl amino}-1,3,4-thiadiazo-5-yl] cyclopropane 5(a-h) have been synthesized from cyclopropane dicarboxylic acid comprising thiadiazole moieties. All the synthesized compounds have been characterized by elemental (C,H,N) and spectral (I.R., 1 H-NMR, Mass) analysis. Furthermore, all synthesized compounds were screened for their antifungal, antimicrobial, anti-inflammatory, analgesic, ulcerogenic and toxic activities. The Compound 5f, 3-chlorophenyl substituted was found the most potent in antimicrobial spectrum against all the used microbes. On the other hand, compound 5g, 4-hydroxy-3-methoxy phenyl substituted was found the most potent in antiinflammatory, analgesic, and ulcerogenic activities which further evaluated for lesser toxicity test.

Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

“…Bis-heterocycles have attracted much attention because of their diverse biological activities [1,2,3]. These include antibacterial, fungicidal, tuberculostatic, and plant growth regulative properties.…”