Synthesis and pharmacology of some dimethoxy-substituted indanamines as potential hypoglycemic agents. 1-Methyl-2-[(dialkylamino)methyl]-5,6-dimethoxyindans

N‐substituted indanamines as potential hypoglycemic agents

“…Hypoglycemic activity was reported among different types of indanamines (1)(2)(3)(4). It was also observed that n-butylpyrrolidine alone possesses appreciable hypoglycemic activity but was extremely toxic (1).…”

“…Therefore, attempts were made to incorporate various such ring systems at the terminal amino nitrogen atom of the indanamine ring moiety and to observe the effect on hypoglycemic activity. All of these compounds were prepared by following a reported procedure (1)(2)(3)(4). Unlike the previous work, both the amides and the corresponding amine hydrochloride salts were used for the pharmacological evaluation of hypoglycemic activity.…”