Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

Efficient synthesis of some novel pyrimido[4,5‐e][1,3]oxazine dione derivatives via one‐pot three‐component reaction under thermal and thermal microwave‐assisted conditions

“…These compounds played an effective role in the synthesis of fused heterocyclic compounds [4,5], such as pyrido-oxazinone, oxazino-quinolinone, oxazino-naphtho [2 0 ,3 0 :4,5]thieno [2,3-d]-oxazine, and pyrimido[5 0 ,4 0 :4,5] pyrrolo [2,4-c]oxazine derivatives [6]. Among fused oxazines, pyrimido [5,4-e] [1,3]oxazines are important due to their various medicinal and biological activities, such as anti-cancer [7], anti-neoplastic effect [8], analgesic [9], anti-diabetes and anti-T2DM agents [10,11], antitumor [12], antibacterial [13], anti-HI [14], analgesic [15], antihypertensive [16], anti-thrombotic [17], anti-ulcer activities [18], anticonvulsant [19], anti-allergic [20], CFTR inhibitors for polycystic kidney disease [21], antiviral [22], antiinflammatory [23], antiprotozoal [24], and antihypertensive [25]. Also, inhibitory effect on the enzymatic system of liver dihydrofolate reductase [26].…”