Synthesis and protein binding properties of novel highly functionalized Calix[4]arene

Highly functionalized calix[4]arenesviamulticomponent reactions: synthesis and recognition properties

“…One of the advantages of using compound 3f as a Lys inhibitor is that the formation of Lys : 3f complex cannot be considerably affected by the presence of biologically important metal ions. 54 In the most recent work, one-pot 4-component reaction of compound 3 with 1,1-bis (methylthio)-2-nitroethylene, 1,2ethanediamine, and malononitrile was carried out in ethanol as solvent and in the presence of 10 mol% piperidine as a basic catalyst under reux condition to afford the new multifunctional calix [4]arene 3g (Scheme 8).…”

Calix[4]arene‐based Multifunctional Ligand as Potent Protein Binding Agent

“…Thus, the synthetic of highly functionalized calix[4]arene derivatives has become an active area of research. Recently, we have reported that highly functionalized calix[4]arenes have significant binding at proteins .…”