Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine

Tripathi, Abhishek; Khan, Amreen; Srivastava, Rohit

doi:10.1007/s00726-023-03314-0

Cited by 2 publications

(3 citation statements)

References 61 publications

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“…Selenium plays an important role in the cell cycle and apoptosis, but these mechanisms are extremely complex and have not yet been fully elucidated . As for tellurium, studies evaluating its biological activity are still scarce, although antineoplastic effects from tellurium compounds are believed to be associated with ROS formation, cell cycle arrest, induction of programmed cell death, and may have immunomodulatory effects, being a class of compounds with great potential to be explored for the development of new anticancer molecules . In this work, we could observe biological activity from all synthesized chalcogen-naphthoquinones derived from both diorganoyl diselenides and diorganoyl ditellurides, with an impact on cell migration, proliferation, and overall survival in OSSC cells.…”

Section: Resultsmentioning

confidence: 92%

“…The exploration of tellurium derivatives as potential anticancer agents has captured considerable attention due to the distinctive chemical properties of this chalcogen. For example, studies conducted by Tripathi et al 63 have already showcased the synthesis of telluroamino acids, demonstrating remarkable anticancer efficacy specifically against the MCF-7 breast cancer cell line. Additionally, research by Barcellos et al 64 has emphasized the pro-oxidant activity of organotellurium compounds, suggesting their potential to induce apoptosis in malignant cells.…”

Section: Resultsmentioning

confidence: 99%

“…54 As for tellurium, studies evaluating its biological activity are still scarce, although antineoplastic effects from tellurium compounds are believed to be associated with ROS formation, cell cycle arrest, induction of programmed cell death, and may have immunomodulatory effects, 55 being a class of compounds with great potential to be explored for the development of new anticancer molecules. 56 In this work, we could observe biological activity from all synthesized chalcogen-naphthoquinones derived from both diorganoyl diselenides and diorganoyl ditellurides, with an impact on cell migration, proliferation, and overall survival in OSSC cells. Also, tellurium-derived especially the compound (10a), showed an increased antineoplastic potential with sufficient selectivity in relation to nontumor cells.…”

Section: Cell Cycle and Cell Death Analysismentioning

confidence: 99%

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New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma

Gomes,

Costa,

Duarte

et al. 2024

ACS Omega

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Due to the growth in the number of patients and the complexity involved in anticancer therapies, new therapeutic approaches are urgent and necessary. In this context, compounds containing the selenium atom can be employed in developing new medicines due to their potential therapeutic efficacy and unique modes of action. Furthermore, tellurium, a previously unknown element, has emerged as a promising possibility in chalcogen-containing compounds. In this study, 13 target compounds (9a−i, 10a−c, and 11) were effectively synthesized as potential anticancer agents, employing a CuI-catalyzed Csp-chalcogen bond formation procedure. The developed methodology yielded excellent results, ranging from 30 to 85%, and the compounds were carefully characterized. Eight of these compounds showed promise as potential therapeutic drugs due to their high yields and remarkable selectivity against SCC-9 cells (squamous cell carcinoma). Compound 10a, in particular, demonstrated exceptional selectivity, making it an excellent choice for cancer cell targeting while sparing healthy cells. Furthermore, complementing in silico and molecular docking studies shed light on their physical features and putative modes of action. This research highlights the potential of these compounds in anticancer treatments and lays the way for future drug development efforts.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Cell Cycle and Cell Death Analysismentioning

confidence: 99%

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New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma

Gomes,

Costa,

Duarte

et al. 2024

ACS Omega

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Following the Trace of Cyclodextrins on the Selenium and Tellurium Odyssey

Morán-Serradilla,

Plano,

Sharma

et al. 2024

IJMS

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There is an urgent need to develop safer and more effective modalities for the treatment of numerous pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Over the past decades, cyclodextrins (CDs) have gathered great attention as potential drug carriers due to their ability to enhance their bioactivities and properties. Likewise, selenium (Se) and tellurium (Te) have been extensively studied during the last decades due to their possible therapeutical applications. Although there is limited research on the relationship between Se and Te and CDs, herein, we highlight different representative examples of the advances related to this topic as well as give our view on the future directions of this emerging area of research. This review encompasses three different aspects of this relationship: (1) modification of the structure of the different CDs; (2) formation of host–guest interaction complexes of naïve CDs with Se and Te derivatives in order to overcome specific limitations of the latter; and (3) the use of CDs as catalysts to achieve novel Se and Te compounds.

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Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine

Cited by 2 publications

References 61 publications

New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma

New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma

Following the Trace of Cyclodextrins on the Selenium and Tellurium Odyssey

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