Synthesis and spectroscopic studies of new bile acid derivatives linked by a 1,2,3-triazole ring

Bile salts and derivatives: Rigid unconventional amphiphiles as dispersants, carriers and superstructure building blocks

“…Nevertheless, even for the bisteroidal the number of possibilities is high enough [83**, 84] to further reduce the research field to be reviewed. Two steroid residues may form acyclic (linear) [84,85] or cyclic derivatives [83**, 86,87], with or without bridges (spacers) between both steroid residues, as well as symmetric or asymmetric and homo-or hetero-derivatives [83**]. In comparison to cyclic derivatives (see, for…”

Spectroscopic methods and theoretical studies of bromoacetic substituted derivatives of bile acids

“…selective N-1-alkylation of 2-thiouracil), 29 ammonium morpholinyl dithiocarbamate (selective S-alkylation), 30 N-1-alkylation of imidazole, 31 sodium azide [32][33][34] or tamoxifen (antagonist of the estrogen receptor in breast tissue). 35 In the case of sodium azide, the resulting products are used as substrates for click chemistry reactions.…”

“…Bile acids can react with halogenoacetic acid halides and potassium carbonate in chloroform or dichloromethane, with calcium or sodium hydride and tetrabutylammonium bromide (TEBA) in toluene, as well as pyridine or 4-(dimethylamino)pyridine (DMAP) in toluene. [27][28][29][30][31][32][33][34][35] These compounds were used in nucleophilic reactions with N-, S-or O-nucleophiles. In many cases bromo-or chloroacetyl substituted derivatives of bile acids react with pyrimidines (e.g.…”

Steroidal Conjugates: Synthesis, Spectroscopic, and Biological Studies

“…In addition, their cytotoxicity was evaluated (Table 6.4) [54]. Intramolecular 1,3-dipolar cycloaddition of the propargyl ester and azide groups of 3a-azidoacetoxy-7a,12a-diformyloxy-5b-cholan-24-oate (79) gave a dimer (80) and tetramer (81) linked by 1,2,3-triazole ring (Scheme 6.9) [55].…”