Synthesis and Structural Characterization of Some Phthalazin-1(2h)-One Uranyl Nitrate Complex Anticancer.

Abstract

A new series of phthalazin-1(2H)-one complex and studying of the spectroscopic like FT-IR , 1H-NMR and HEPG-2 properties as application of complex The biological activity as antitumor. compound has an significant anticancer activity against human liver carcinoma cells HEPG-2 to the ligand and the determine the urinal nitrate complex …………………………………………………………………………………………………….... Introduction:-Studying of ligands and the metal complex has a very effective role in many area of chemistry application one of most important ligands is the heterocyclic compound containing N-donor atom the interest of the ligands due to photo physical , biological and spectroscopic properties, phthalazine is one of azines which are potentially bidentate ligand that use to form metal complex, phthalazin-1(2H)-one are studied with many metal for example Mn,Fe,Co,Ni,Cu,Zn,Cd,Ir,V and Ru.1-8 the main interest of the phthalazin-1(2H)-one complex due to the spectroscopic properties as an important application of complex and The biological activity as antitumor, hypotensive, antifungal and antimicrobial of this complex give the attention to be studded from many way 7,9 . the complexes of phthalazine with heavy metal play a very important role in forming organic light-emitting diodes (OlEDs) on of base of the forming due to founding sp 2 -hybird N in the ligand due to the spin-orbit of heavy-metal ions is phosphorescent complex's 10-13 the complex with iridium is promising OLED for full color panel display 8,14,15 the important of using phthalazine BPPa[1,4-bis(phenyl) phthalazine] in synthesis of dinuclear complexes due to the ability to forming metal-metal separation range from 2.550A 0 to 4.045 A 0 8 , bdptz{1,4-bis(2,2'-dipyridylmethyl)phthalazine} and Ph 4 bdptz {1,4-bis[bis(6-phenyl-2-pyrdyl)methyl] phthalazine} is used to prepare dinuclear compounds with different transition metal ions as hydrophobic pocket [16][17][18][19][20] . N-donor ligands with urinal nitrate as complex give antitumor activity as complexes against a panel of human tumor cell lines (HT29: Haman colon adenocarcinoma cell line T47D human breast adenocarcinoma cell line), significant anticancer activity against Ehrlich ascites tumor cells 21-29.