Synthesis and structure of the unsymmetrical P-diastereoisomer of 1,6-dichloro-1,6-didesoxy-2,4;3,5-bis-O-(piperidinophosphoryl)-D-mannitol

New tagged naplephos ligands for asymmetric allylic substitutions under traditional and unconventional conditions

“…In naplephos-a 0 and naplephos-h 0 the phosphorous atom of the phosphate ring is stereogenic, and two diastereomers can be in principle observed in solution. Notably, even though not completely unexpectedly, 12 the NMR spectra reveal that both ligands exist as a unique diastereomer.…”