Synthesis and structures of a pincer-type rhodium(<scp>iii</scp>) complex: reactivity toward biomolecules

Milutinović, Milena; Bogojeski, Jovana; Klisurić, Olivera R.; Scheurer, Andreas; Elmroth, Sofi K. C.; Bugarčić, Živadin D.

doi:10.1039/c6dt02772e

Cited by 31 publications

(28 citation statements)

References 45 publications

(24 reference statements)

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“…0.41 ± 0.01 0.24 ± 0.02 [35] [Rh(Me 2 L*)Cl 3 ] (9) 5.6 ± 0.1 0.38 ± 0.01 [36] [Rh(terpy)Cl 3 ] (10) 0.40 ± 0.01 0.034 ± 0.001 [36] are more reactive compared to analogue platinum complexes (10 3 -10 5 times), that was expected. [13] In addition, complexes with H 2 L tBu inert ligand (1 and 3) showed slightly higher reactivity than those with Me 2 L tBu (2 and 4), indicating the steric influence of chelating ligands on the reactivity of complexes.…”

Section: Substitution Reactionsmentioning

confidence: 97%

“…The kinetic and mechanism of the substitution reactions of studied complexes (Figure 1) with important biological ligands such as thiourea (tu), L-methionine (L-met), L-cysteine (L-cys), glutathione (GSH) and guanosine-5'-monophosphate (5'-GMP) were studied. [33][34][35][36] Some obtained results are given in the Table 1.…”

Section: Substitution Reactionsmentioning

confidence: 99%

“…Similar observations were reported by Bogojeski et al for the kinetic reactivity of Rh(III) pincer complexes with bis-pyrazolylpyridine ligands and for Rh(III)-terpy complexes. [35,36] In addition, we have chosen to study the same type of complexes with Rh(III) as metal ion, since in recent years complexes of Rh, Os and Ir have been intensively examed in relation to possible anti-tumor activity. According to the obtained data (Table 1), studied Rh(III) complexes are reactive toward all of the tested nucleophiles, with order of reactivity 5′-GMP > GSH > L-met.…”

Section: Substitution Reactionsmentioning

confidence: 99%

See 2 more Smart Citations

Bis-pyrazolylpyridine Complexes of Some Transition Metal Ions: Structure-Activity Relationships and Biological Activity

Simović¹,

Bogojeski²,

Petrović³

et al. 2020

MHC

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Section: Substitution Reactionsmentioning

confidence: 97%

Section: Substitution Reactionsmentioning

confidence: 99%

Section: Substitution Reactionsmentioning

confidence: 99%

See 1 more Smart Citation

Bis-pyrazolylpyridine Complexes of Some Transition Metal Ions: Structure-Activity Relationships and Biological Activity

Simović¹,

Bogojeski²,

Petrović³

et al. 2020

MHC

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“…36 The absorption intensity of the complex may decrease (hypochromism) or increase (hyperchromism) with a slight increase in the absorption wavelength (bathochromism) upon addition of DNA. 36,37 A studied system of adding CT-DNA to a solution of studied complex resulted in a significant hyperchromic effect with the appearance of a new band at 258 or 257 nm, but with only insignificant absorption changes in the region 300-500 nm, see Fig. 2.…”

Section: Uv-vis Absorption Studiesmentioning

confidence: 98%

“…The other dependences were similar and they did not give a significant hyperchromic shift with the appearance of a new signal in the UV-Vis spectra, which clearly suggested an interaction between the complexes and CT-DNA. [37][38][39] Fig. 2.…”

Section: Uv-vis Absorption Studiesmentioning

confidence: 99%

Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms

Raković

Radojević

Mladenović

et al. 2018

JSCS

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The antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl] + (C1), [Pd(en)Cl 2 ] (C2), [Pd(DMEAIm iPr)Cl 2 ] (C3) and [Pd(dach)Cl 2 ] (C4) (terpy = 2,2′:6′,2′′-terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DMEAIm iPr = N 2-((1,3-dihydro-1,3-diisopropyl-4,5-dimethyl)-2H-imidazol-2ylidene)-N 1 ,N 1-dimethyl-1,2-ethanediamine are reported. The antimicrobial activities of the Pd(II) complexes with the appropriate ligands were tested using the microdilution method against 18 strains of microorganisms, whereby the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) were determined. The antibiofilm activity of [Pd(terpy)Cl] + and the corresponding ligand were determined on a formed biofilm. The intensity of antimicrobial activity varied depending on the type of microorganism and the tested compound. The C1 complex with the corresponding ligand demonstrated significantly greater overall antimicrobial activity than C2, C3 and C4. The antibacterial activity of the C1 complex was better than its antifungal activity that was overall greater than that of the positive control, fluconazole. The greatest sensitivity for C1 and L1 was with Penicillium italicum (MIC < 0.49 μg mL-1) among the fungi, and with Proteus mirabilis ATCC 12453 (MIC = 0.98 μg mL-1) among the tested bacteria. The tested compounds show low and moderate antibiofilm activity. The complexes showed weak antioxidant properties when tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The interaction of the metal complexes C1-C4 with calf thymus DNA (CT-DNA) was further examined by absorption (UV-Vis) and emission spectral studies (EthBr displacement studies). Overall, the investigated complexes exhibited good DNA interaction ability.

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Supramolecular interaction of transition metal complexes with albumins and DNA: Spectroscopic methods of estimation of binding parameters

Galkina

Проскурнин

2018

Applied Organom Chemis

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Binding parameters of metal complexes with albumins and DNA since the middle of 1990s are considered and summarized. The most widespread spectroscopic methods of estimation of binding parameters are discusseddirect fluorescent methods, indirect fluorescent methods (by fluorescence quenching parameters), and ways of estimation of binding constants by other optical spectroscopic methods. The methods and approaches to calculations used for the determination of binding constants are discussed. The data on the already found binding constants and kinetic parameters is systematized.KEYWORDS albumins, DNA, metal complexes, proteins, supramolecular interaction Funding information: Russian Foundation for Basic Research, Grant/Award Number: 16-03-01089_a 16-53-50027_YaF_a Abbreviations and designations used: F 0 , fluorescence intensity in the absence of a quencher; F, fluorescence intensity in the presence of a acid); NTSC, a new thiosemicarbazone; o-cbiaH, 5-(2-carboxybenzyloxy)isophthalic acid; o-van-gln, a Schiff base derived from o-vanillin and glutamine; o-van-L-met, Schiff base derived from o-vanillin and L-methionine; oxo, 5-

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Synthesis and structures of a pincer-type rhodium(iii) complex: reactivity toward biomolecules

Cited by 31 publications

References 45 publications

Bis-pyrazolylpyridine Complexes of Some Transition Metal Ions: Structure-Activity Relationships and Biological Activity

Bis-pyrazolylpyridine Complexes of Some Transition Metal Ions: Structure-Activity Relationships and Biological Activity

Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms

Supramolecular interaction of transition metal complexes with albumins and DNA: Spectroscopic methods of estimation of binding parameters

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