Synthesis and Study of Modified Polyvinyl Alcohol Containing Amino acid moieties as Anticancer Agent

Abstract

A series of new phthalimides compounds [3][4][5][6][7] a-i were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo [d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo [d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1] a-i under fusion conditions. Compounds [3-7] a-i react with SOCl 2 in the presence of benzene to produce compounds [8-12] a-i . Chemical modification of Poly(vinyl alcohol)were obtained by reaction of PVA with compounds [8-12] a-i using the dimethyl formamide to give compounds [13-17] a-i . The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra, 1 H, 13 C-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.

Synthesis and Characterization of O-(carboxyl) Chitosan Schiff Base Derivatives and Study Antibacterial Activity

“…FTIR of compound [5], Figure 5 showed a big peak at 3,411 cm -1 , which refers to the stretch of N-H and O-H from the intra-and extra-molecular hydrogen bonding of chitosan molecules, and showed off a new band at 1,707 cm -1 , which refers to C=O group of ester. 15 Compounds [6][7][8][9] had synthesized by the reaction of O-(carboxyl) chitosan [5] with aromatic aldehydes. FTIR of compound [8] Figure 6 shows a presence of a big peak at 3,448 cm -1 , which refers to the stretch of O-H and N-H from the intra-and extra-molecular hydrogen bonding of chitosan molecules, and showed a new band at 1,710 cm -1 , due to C=O group of ester, and appeared 1,641, corresponding to the C=N characteristic vibration of imines.…”