Synthesis andin vitro tuberculostatic activity of podands containing semicarbazide or thiosemicarbazide fragments

Федорова, О. В.; Mordovskoi, G. G.; Rusinov, Gennady L.; Овчинникова, И. Г.; Zueva, M. N.; Кравченко, М. А.; Чупахин, О. Н.

doi:10.1007/bf02464163

Cited by 10 publications

(6 citation statements)

References 3 publications

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“…Gần đây, podand được tập trung nghiên cứu trong vai trò là tác nhân quan trọng tổng hợp các hợp chất azacrown ether trên cơ sở các các phản ứng ngưng tụ đa tác nhân như: phản ứng Petrenko-Krischenko [9][10][11][12][13][14] và phản ứng Hantzsch [15][16][17]. Ngoài ra các hợp chất podand có chứa các dị tố nitơ, lưu huỳnh đã được tổng hợp thành công và bước đầu thể hiện một số hoạt tính sinh học hữu ích như: hoạt tính kháng vi sinh vật kiểm định và kháng vi trùng lao (in vitro test) [6,[18][19][20] .…”

Section: Mở đầU *unclassified

“…Trên cơ sở phản ứng ngưng tụ aldol và chuyển hóa croton, từ các tiền chất podand 1,7-bis-(2-oxo-phenyl)-4-oxaheptane (1a-d) và dẫn xuất benzaldehyde/acetophenone đã tổng hợp thành công nhóm các heteropodand (3,4) (Sơ đồ 1). Dẫn xuất podand với các nhóm chức vinylketone liên hợp gia tăng khả năng tạo phức với các ion kim loại và hứa hẹn thể hiện một số hoạt tính sinh học hữu ích [19,21,22]. ; ; Sơ đồ 1.…”

Section: Kết Quả Và Thảo Luậnunclassified

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Synthesis and Structural Characterization of some 3-oxapentane Podand Derivatives

Linh

Tam²,

Thuyen³

et al. 2023

NST

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A series of eight 3-oxapentane podand derivatives was successfully prepared based on the croton condensation reaction from 1,5-bis(aryl)-1,5-dithia-3-dioxadecane and 1,5-bis(aryl)-1,3,5-trioxadecane with bezaldehyde or acetophenone derivatives in acidic condition. These synthesized derivatives have structure of acyclic crown rings inserted by polyether or polythiaether chain and vinyl ketone chain conjugated with aryl group. Therefore, they are important sources for host-guest chemistry. They can wrap around a central alkali metal cations as well as organic cations and anions or even molecules to make interesting ion pair receptors. Structure of new podands was determined by spectral analyses including IR, 1H NMR, MS spectrocopies.

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Section: Mở đầU *unclassified

Section: Kết Quả Và Thảo Luậnunclassified

Synthesis and Structural Characterization of some 3-oxapentane Podand Derivatives

Linh

Tam²,

Thuyen³

et al. 2023

NST

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“…Over the last decade, considerable progress has been made in the field of antineoplastics derived from thiosemicarbazones, but so far not many semicarbazones have been developed [1]. Semicarbazones appear to have a broad spectrum of therapeutic activity especially as anticonvulsants [2,3], tuberculostatics [4], antitrypanosomals [5] etc. Dimmock et al [6] reported the antileukemic activity of thiosemicarbazone and semicarbazone derivatives and the semicarbazones were found to be less toxic.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antitumour Evaluation of 4-Bromophenyl Semicarbazones

Pandeya¹,

Yogeeswari²,

Sausville

et al. 2011

Arzneimittelforschung

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4-Bromophenyl semicarbazone derivatives have been synthesized and their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analyses. The in vitro evaluation in the 3-cell line, one dose primary anticancer assay is described. The 4-bromo substituted p-nitrobenzylidene phenyl semicarbazone (5) showed significant activity against breast MCF7 cell line and was further evaluated for potential anticancer activity in an in vitro human disease-oriented tumour cell line screening panel that consisted of 59 human tumour cell lines arranged in nine subpanels, representing diverse histologies. Melanoma UACC-62 cell line was relatively more sensitive to compounds 5 (growth inhibitions: GI50 = 15.3 mumol/l).

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“…2-Aryl indole derivatives also displayed diverse biological activities such as antiestrogen (Ismail et al, 1997;FungTomc et al, 2002) antiinflammatory (Von Angerer et al, 1900;Biberger and Von Angerer, 1998) cytotoxic (Stevenson et al, 2000) and antimitotic (Doris Kaufmann et al, 2007;Mahboobi et al, 2005) activities. Semicarbazones also possessed various therapeutic activities (Dimmock and Baker, 1994;Jenny et al, 2002. Fedorova et al, 1998.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial activity of newer indole semicarbazones

Laxmi

Rajitha

2010

Med Chem Res

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A series of 1-(2-Oxo-2-phenyl-ethyl)-2-phenyl-1H-indole-3yl)methylene) semicarbazone derivatives (4a-g and 6a-c) were synthesized by the condensation of derivatives of 1-(2-Oxo-2-phenyl-ethyl)-2-phenyl-1H-indole-3-carbaldehyde and semicarbazide in ethanol under microwave irradiation procedure. Both conventional and microwave-irradiated syntheses have been carried out to compare their yields and reaction time. The structures of the synthesized compounds were confirmed by spectral data. The antimicrobial activities of the synthesized compounds were screened using broth dilution method. Among all the screened compounds some of the compounds exerted good antifungal activity against C. albicans and C. rugosa. All the compounds exhibited moderate activity against bacteria such as B. subtilis, S. aureus, S. epidermidis, E. coli, P. aeoginosa, and K. pneumoniae.

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Synthesis andin vitro tuberculostatic activity of podands containing semicarbazide or thiosemicarbazide fragments

Cited by 10 publications

References 3 publications

Synthesis and Structural Characterization of some 3-oxapentane Podand Derivatives

Synthesis and Structural Characterization of some 3-oxapentane Podand Derivatives

Synthesis and Antitumour Evaluation of 4-Bromophenyl Semicarbazones

Synthesis and antimicrobial activity of newer indole semicarbazones

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