Synthesis, antibacterial screening, and POM analyses of novel bis-isoxazolyl/pyrazolyl-1,3-diols

Chiral differentiation of novel isoxazoline derivatives on “clicked” thioether and triazole bridged cyclodextrin chiral stationary phases

“…Such compounds possess various biological activities such as insecticidal, antibacterial, antibiotic, antitumour, antifungal, antimicrobial, in vitro anti-tuberculosis activity and anti-inammatory activities. [1][2][3][4][5][6][7][8][9] In addition, isoxazoline derivatives have been recognized as important intermediates for the synthesis of alkaloids and other natural products. 10,11 Small pharmaceutical compounds with substituted isoxazoline rings such as some phenylisoxazolines exhibit high activity against gram-positive pathogens.…”

Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners

“…One of the practical problems associated with synthetic drugs is the existence of various side effects. Shown in Table 2 are results of theoretical toxicity risks of compounds 1 – 7 calculated with the aid of the Petra/Osiris/molinspiration (POM) program [ 32 , 33 , 34 , 35 ]. Our findings reveal that compounds 2 , 4 , 6 and 7 , contrary to compounds 1 , 3 and 5 , are not toxic and can be utilized as therapeutic agents.…”

Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive

“…An interesting aspect of this study is that not all compounds (except C-8 and C-9) do obey the Rule of 5, and exert some violation of this cardinal rule. Two or more violations of the Rule of 5 suggest the probability of problems in bioavailability of the standard drug [20,[29][30][31][32][33].…”