Synthesis, anticancer, and molecular docking studies of pyranone derivatives

Swamy, P. M. Gurubasavaraja; Sri, B. Ramya; Giles, D.; Shashidhar, Byrappa Venkataraju; Das, Amit Kumar; Agasimundin, Y. S.

doi:10.1007/s00044-013-0478-7

Cited by 8 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our design supported from our previous findings [10][11][12][13][14][15] addressed the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole [16][17][18][19][20][21][22][23][24][25][26] and a chalcone, [27][28][29] to yield a class of compounds with interesting antimicrobial properties…”

Section: Introductionmentioning

confidence: 60%

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

Λιάρας¹,

Geronikaki²,

Glamočlija³

et al. 2011

Bioorganic & Medicinal Chemistry

141

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 60%

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

Λιάρας¹,

Geronikaki²,

Glamočlija³

et al. 2011

Bioorganic & Medicinal Chemistry

141

View full text Add to dashboard Cite

Synthesis and characterization of aniline‐based azo molecules: In vitro pharmacological and emission studies

Shakuntala,

Keshavayya,

Mussuvir pasha

et al. 2024

Luminescence

View full text Add to dashboard Cite

The present work involves the synthesis of novel dispersed mono‐azo dyes using different coupling components and 2‐methoxy‐5‐nitro aniline as amine through a simple and convenient diazo‐coupling method. The structures of the newly synthesized mono azo dyes were confirmed by using various spectral techniques such as 1H NMR, Fourier transform infrared, and high‐resolution mass spectrometry. At room temperature, the electronic absorption spectra and fluorescence spectra of the synthesized mono azo dyes were recorded with different solvents. The global reactive parameters for the synthesized azo molecules were evaluated by performing density functional theory through the 6–311++G (d, p) basis set. The anti‐microbial activities for the synthesized azo compounds were carried out, and the compounds G1 and G2 exhibited good antibacterial and anti‐fungal activities. The in silico molecular docking studies of the azo molecules revealed that all the compounds exhibited extraordinary binding affinity as that of the standard drug. Further, the anti‐tuberculosis study against the Mycobacterium tuberculosis for the synthesized azo dyes was evaluated, and from the results, it was revealed that the compound G4 showed good sensitivity among the other synthesized azo compounds.

show abstract

Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines

Parekh

Mistry

Pandurangan

et al. 2017

Chinese Chemical Letters

View full text Add to dashboard Cite

Synthesis, anticancer, and molecular docking studies of pyranone derivatives

Cited by 8 publications

References 20 publications

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

Synthesis and characterization of aniline‐based azo molecules: In vitro pharmacological and emission studies

Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines

Contact Info

Product

Resources

About