Synthesis, antihyperglycemic activity and computational studies of antioxidant chalcones and flavanones derived from 2,5 dihydroxyacetophenone

Tajammal, Affifa; Batool, Majda; Ramzan, Ayesha; Samra, Malka M.; Mahnoor, Idrees; Verpoort, Francis; Irfan, Ahmad; Munawar, Munawar Ali; Basra, Muhammad Asim Raza

doi:10.1016/j.molstruc.2017.07.042

Cited by 31 publications

(21 citation statements)

References 41 publications

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“…Analyzing antioxidant protection in terms of the intrinsic reactivity of the antioxidant species is, by far, the theoretical approach most frequently found in the literature . There are several reactivity indexes that have been used for that purpose.…”

Section: The Computational Approachmentioning

confidence: 99%

Computational strategies for predicting free radical scavengers' protection against oxidative stress: Where are we and what might follow?

Galano

Álvarez-Idaboy

2018

Int J of Quantum Chemistry

213

247

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Oxidative stress, which is frequently induced by an overproduction of free radicals (FR), poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a research area of current interest. Among many other aspects, this involves identifying chemical compounds capable of offering antioxidant protection (AOP) and quantifying such protection. This review summarizes different computational approaches that can contribute to gain a deeper knowledge on this subject. Several reaction mechanisms that may contribute to AOP are discussed, as well as some key factors influencing their relative importance including the chemical nature of the reacting FR, the polarity of the environment and the pH in aqueous solution. Kinetics‐based analyses to characterize antioxidants, through their FR scavenging activity, are presented. Trends in such activity, from the data currently available in the literature are provided. Some key aspects, regarding AOP, that still deserves further investigation, are discussed.

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Section: The Computational Approachmentioning

confidence: 99%

Computational strategies for predicting free radical scavengers' protection against oxidative stress: Where are we and what might follow?

Galano

Álvarez-Idaboy

2018

Int J of Quantum Chemistry

213

247

View full text Add to dashboard Cite

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“…The chalcones (49) were studied as potent antioxidants by Tajammal and coworkers. These compounds have lower IC 50 values than the Trolox and ascorbic acid standards [51].…”

Section: Antioxidant Chalconesmentioning

confidence: 83%

Biological Role of Chalcones in Medicinal Chemistry

Tekale¹,

Mashele²,

Pooe³

et al. 2020

Vector-Borne Diseases - Recent Developments in Epidemiology and Control

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Chalcones are promising synthons and bioactive scaffolds of great medicinal interest due to their numerous pharmacological and biological activities. They are well recognized to possess antimicrobial, anticancer, antitubercular, antioxidant, anti-inflammatory, antileishmanial, and other significant biological activities. This chapter highlights recent updates and applications of chalcones as biologically, pharmacologically, and medicinally important entities.

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“…Several authors have evaluated the antihyperglycemic activity of synthetic chalcones in streptozotocin-induced diabetic rats ( Satyanarayana et al, 2004 ; Shukla et al, 2007 ; Najafian et al, 2010 ; Rawat et al, 2011 ; Mahapatra et al, 2017a ; Sengupta et al, 2017 ; Shukla et al, 2017 ; Tajammal et al, 2017 ; Acharjee et al, 2018 ; Naidu, 2018 ; Raju et al, 2018 ). It was found that these compounds have a moderate to potential ability to reduce blood sugar.…”

Section: Preclinical Pharmacological Activities Of Chalconesmentioning

confidence: 99%

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

et al. 2021

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Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules.

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Synthesis, antihyperglycemic activity and computational studies of antioxidant chalcones and flavanones derived from 2,5 dihydroxyacetophenone

Cited by 31 publications

References 41 publications

Computational strategies for predicting free radical scavengers' protection against oxidative stress: Where are we and what might follow?

Computational strategies for predicting free radical scavengers' protection against oxidative stress: Where are we and what might follow?

Biological Role of Chalcones in Medicinal Chemistry

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

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