Synthesis, antiinflammatory and antimicrobial activity of some new 1-(3-Phenyl-3,4-Dihydro-2H-1,3-Benzoxazin-6-yl)-ethanone derivatives

Abstract

Synthesis of title compounds (4a-j) was carried out by following aminomethylation Mannich reaction. Test compounds were effective in inhibiting edema induced by carrageenan. The percent inhibition obseved was in the range of 25-83.3%. Compound (4c, e, h and j) were also tested for analgesic effect and showed percent protection ranging between 57-65%. All the synthesized compounds were active against E. coli and S. aureus but only compounds (4 b, c, e, i and j) were active against B. subtilis. All these compound were also found active against A. niger. Compound 4j was the most active compound with 83.3% inhibition of edema, 65.35% percent protection and inhibited all the three bacterial strains.

SOLID SiO2-H3PO4 IS AN EFFICIENT CATALYST FOR CYCLIZATION OF ENONES UNDER SOLVENT-FREE CONDITION: SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME OXAZINE DERIVATIVES

“…These oxazines were medicinally important due to the presence of oxygen, nitrogen heteroatoms along with a double bonds in their structural moieties 3 . The important medicinal activities of these oxazines are anti-bacterial, antifungal [3][4][5] , anti-plasmodial 6 , anti-cancer 7 , anti-depressants 8 , cytotoxicity 9 , anti-osteoplastic 10 , anti-tumour 11 , anti-oxidant 12 , anti-tuberculosis 13 , antineoplastic 14 , antagonists 15 , anti-inflammatory 16 , anti-infectants 17 , IKB kinase beta 18 and PTP-1B inhibition 19 . These oxazine derivatives were applied for improving the super resolution microscope 20 , synthesis of eosinophils 21 , identification and separation of neutrophils 22 .…”

Infrared and NMR Spectral Hammett Correlations in 4-(2-Naphthyl)-5,6-Dihydro-6-(Substituted Phenyl)-⁴H-1,3-Oxazine-2-Amines

“…The unsaturated cyclic oxazine-2-amines are important bioactive molecules. They possess many biologically activities such as antimicrobial [9], anti-plasmodial [10], anti-cancer [11], anti-depressants [12], cytotoxicity [13], anti-osteoplastic [14], anti-tumour [15], anti-oxidant [16], anti-tuberculosis [17], anti-neoplastic [18], antagonists [19], antiinflammatory [20] anti-infectants [21], IKB kinase beta [22], PTP-1B inhibition [23] and insect antifeedant activities [24].…”

Hydroxyapatite catalyzed cyclization of aryl enones: Solvent-free efficient synthesis of some 4-aryl-5,6-dihydro- 6-(substituted phenyl)-4H-1,3-oxazine-2-amines

“…These oxazines were medicinally important due to the presence of oxygen, nitrogen heteroatoms along with a double bonds in their structural moieties [4]. The important medicinal activities of these oxazines are anti-bacterial, anti-fungal [4][5][6], anti-plasmodial [7], anti-cancer [8], anti-depressants [9], cytotoxicity [10], anti-osteoplastic [11], anti-tumour [12], anti-oxidant [13], anti-tuberculosis [14], anti-neoplastic [15], antagonists [16], antiinflammatory [17], anti-infectants [18], IKB kinase beta [19] and PTP-1B inhibition [20]. These oxazine derivatives were applied for improving the super resolution Microscope [21], synthesis of eosinophils [22], identification and separation of neutrophils [23].…”