Synthesis, antimicrobial activity and docking studies of new N-ethyl-3-indolyl heterocycles

El-Sayed, Weal A.; Abbas, Hebat‐Allah S.; Mageid, Randa E. Abdel; Magdziarz, Tomasz

doi:10.1007/s00044-015-1488-4

Cited by 7 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides the abovementioned indole–pyrimidine hybrids, some other indole derivatives bearing pyrimidine moiety also possessed a certain antibacterial activity. [ 162–169 ] However, the majority of them were far less potent than the reference drugs. Despite this, the SAR was enriched and the enriched SAR may pave the way for further rational design.…”

Section: Indole–pyridine/pyrimidine Hybridsmentioning

confidence: 99%

Indole/isatin‐containing hybrids as potential antibacterial agents

Song

Bian

et al. 2020

Archiv der Pharmazie

View full text Add to dashboard Cite

The emergence and worldwide spread of drug-resistant bacteria have already posed a serious threat to human life, creating the urgent need to develop potent and novel antibacterial drug candidates with high efficacy. Indole and isatin (indole-2,3-dione) present a wide structural and mechanistic diversity, so their derivatives possess various pharmacological properties and occupy a salient place in the development of new drugs. Indole/isatin-containing hybrids, which demonstrate a promising activity against a panel of clinically important Gram-positive and Gram-negative bacteria, are privileged scaffolds for the discovery of novel antibacterial candidates. This review, covering articles published between January 2015 and May 2020, focuses on the development and structure-activity relationship (SAR) of indole/isatincontaining hybrids with potential application for fighting bacterial infections, to facilitate further rational design of novel drug candidates.

show abstract

Section: Indole–pyridine/pyrimidine Hybridsmentioning

confidence: 99%