Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole

In vitro antimicrobial studies of new benzimidazolium salts and silver N-heterocyclic carbene complexes

“…The synthesized compound was crystallized from a dichloromethane/diethyl ether (2:1) mixture at room temperature. The antimicrobial activities of 13 compounds (1a-g; 2a-f) were obtained in vitro using the agar-well diffusion method 19 . The stock solutions (10 mg/ml À1 ) of the compounds were prepared by dissolving them in dimethyl sulfoxide (DMSO).…”

“…In particular, this nucleus is a constituent of vitamin-B12 17 . Benzimidazoles are regarded as a promising class of bioactive heterocyclic compounds, which have attracted considerable interest in medicinal chemistry because of their various range of biological activities including antiviral, anticancer 16,18,19 , antimicrobial 1,16,[18][19][20] , anti-inflammatory 16,19 , anthelmintic, antihistaminic, proton pump inhibitor, antioxidant, antihypertensive and anticoagulant activities 16 . The aim of this study was to investigate the in vitro antimicrobial activity of new synthesized benzimidazolium salts (1a-f) and Ag-NHC complexes (2a-g), which were formed in situ deprotonation with silver oxide of 1a-f.…”

The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives

“…In addition, substitution of electron withdrawing groups such as amino, nitro, trifluoromethyl, and halogens especially at the 6 th position enhances the antimicrobial and antifungal activities [3][4][5][6][7][8][9][10][11][12][13] . In their literature review, Keri et.al.…”

Synthesis of novel pyridine linked to benzimidazole via sulphide and their Antioxident and Antimicrobial activity

“…Ethyl 2-(4-(trifluoromethyl)phenyl)-1-(2-morpholinoethyl)-1H-benzo[d] imidazole-5-carboxylate was found to be the most promising inhibitor of Mycobacterium tuberculosis H37Rv active 4 with IC50 of 11.52 μM. Benzimidazole bearing 2-pyridones derivatives ware evaluated for their in vitro antibacterial and found to possess significant broad spectrum antibacterial activity (12.5-100 μg/mL of MIC) 5 .Pyrimidinylbismethyl thiobenzimidazole derivatives was a potent antimicrobial agent particularly against Staphylococcus aureus (MIC12.5 μg/mL) 6 .1,3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potent anticancer 7 , anti-microbial 8 .…”