Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives

Fassihi, Afshin; Abedi, Daryoush; Saghaie, Lotfollah; Sabet, Razieh; Fazeli, Hossein; Bostaki, Ghasem; Deilami, Omid; Sadinpour, Hekmatollah

doi:10.1016/j.ejmech.2008.10.022

Cited by 75 publications

(64 citation statements)

References 39 publications

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“…They contain either hydroxamate or catechol groups, which are able to sequester iron cations (Hider et al, 1992). Chelating ability of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one), which has a catechol-like function, has been used for analytical purposes, also plays a significant role in its antibacterial and antifungal activities (Weinberg, 1957;Synytsya et al, 2008;Fassihi et al, 2009). Also, metal-binding compounds which were formed by the reaction of hydroxypyranone derivatives with metallic ions have proven activities in fungal infectious (Brtko et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives

Aytemir

Özçelık

2010

Med Chem Res

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A novel series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antibacterial, antifungal and antiviral in vitro properties. In the view of activity results, compounds 8-11 (MIC: 8 lg/ml) were more remarkably active against Staphylococcus aureus and Enterococcus faecalis. Compounds 1-7 were highly active against Candida albicans and C. parapsilosis with MIC value of 8 lg/ml. Compound 9 bearing 3-chlorophenyl moiety was determined to be the most active compound against RNA virus PI-3.

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Section: Introductionmentioning

confidence: 99%

“…Previous antimicrobial activity studies showed that kojic acid and its derivatives have antibacterial activity (Kotani et al, 1975;Pirselova et al, 1996;Aytemir et al, 2003;Bentley, 2006;Fassihi et al, 2009). Moreover, 2-chloromethyl-5-hydroxy-4H-pyran-4-one (chlorokojic acid) inhibited Aeromonas aerogenes, Micrococcus pyogenes var.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives

Aytemir

Özçelık

2010

Med Chem Res

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“…The dependence of antimicrobial activity of the synthesized compounds on composite physical or quantum chemical parameters was investigated by developing some quantitative structure activity relationship (QSAR) model equations. The use of multiple linear regression (MLR) analysis in correlating biological activity of organic molecules to their molecular structures and electronic parameters is very popular in drug design (Fassihi et al, 2009;Deeb et al, 2007;Mandloiet al, 2005;Rasuleyet al, 2005;Hemmateenejad et al, 2002;Lien et al, 1999). If carefully developed, QSAR (MLR) models can be successfully used to predict biological activity of molecules (Mandloi et al, 2005;Hemmateenejad et al, 2002).…”

Section: Homo Lumomentioning

confidence: 99%

Synthesis, antimicrobial activities and computational studies of some oxazolone derivatives

Olomola¹,

Akinboye²,

Olasunkanmi³

et al. 2018

Ife Journal of Science

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Synthesis of the oxazolone derivatives was achieved by the condensation of aromatic aldehydes with N-acetyl glycine in the presence of acetic anhydride and anhydrous sodium acetate. A total of six oxazolones were 1 13 synthesized and characterized using H-NMR, C-NMR and FT-IR spectroscopic techniques. The synthesized compounds were screened for their in vitro antibacterial and antifungal activities using streptomycin and ampicillin as control. The result showed that some of the compounds demonstrate good antibacterial activities against specific bacterial strains and moderate activities against other bacterial strains. The compounds did not show any sensitivity against the tested fungal strains. The quantitative structure-antibacterial activity relationship was studied using some quantum chemical parameters with the aid of Spartan 10 (V1.0.1) and XLSTAT (add-in) software. A good correlation was observed between the antibacterial activity of the compounds and the calculated quantum chemical descriptors.

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“…Od ostalih vrsta bioloških aktivnosti koju pokazuju derivati 3,4-HP treba još spomenuti antimalarijsku, 36 antibakterijsku 37 te antiadhezijsku 4 aktivnost. Pokazalo se da ti spojevi mogu inhibirati rast mnogih bakterija te da je, osim sposobnosti keliranja željeza, nekoliko dodatnih strukturnih faktora važno u pokazivanju navedenog učinka.…”

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3-Hidroksipiridin-4-oni (II. dio): Biološka primjena kao kelatora željeza

et al. 2017

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Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives

Cited by 75 publications

References 39 publications

Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives

Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives

Synthesis, antimicrobial activities and computational studies of some oxazolone derivatives

3-Hidroksipiridin-4-oni (II. dio): Biološka primjena kao kelatora željeza

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