Synthesis, Antioxidant, Molecular Docking And DNA Interaction Studies of Metal Based Imine Derivatives

Abstract

Background: Currently, numerous investigations are ongoing into the interaction of free radicals with biological systems such as lipids, DNA and protein. Methods: In the present work, synthesis, characterization, antioxidant, DNA binding and molecular docking studies of Schiff base ligand and its Ni(II), Co(II), Cu(II) and Zn(II) were evaluated. Results: The metal complexes shown significant dose-dependent antioxidant activities comparable to the classical antioxidants, ascorbic acid and ethylene diaminetetraacetic acid (EDTA). The DNA binding constants (kb) were found to be 3.487×10-5M-1, 1.858×10-5M-1, 3.090×10-5M-1, 1.367×10-5M-1 and 9.118×10-5M-1 for Ni(II), Co(II), Cu(II) and Zn(II) metal complexes, respectively. Binding constants (Kb) and free energy (∆G) values calculated from molecular docking analysis were found to be in close agreement with experimental results.Conclusion: The obtained results indicate the importance of synthesis complexes as a source of synthetic antioxidants and anticancer drugs.