Synthesis, antitumor evaluation, molecular modeling and quantitative structure–activity relationship (QSAR) of some novel arylazopyrazolodiazine and triazine analogs

Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives

“…However, most cancer chemotherapeutic agents severely affect the most normal cells [48]. So, it is very important to find some new anticancer chemical entities which have less toxicity to host cell [49,50]. The use of heterocyclic compounds played an important role in the control of cancer and its eradication program.…”

Utility of thiocarbamoyl moiety in synthesis of some new sulphur containing heterocyclic compounds and evaluation of their antimicrobial activity

“…Now, we have extended our synthetic program to the synthesis of otherwise inaccessible heterocyclic ring system, utilizing phenyl isothiocyanate as a key starting material. It is known that a great variety of reactants bearing the N=C=S fragment undergo cyclization on reaction with α-halocarbonyl compounds to afford thiophenes [18][19][20][21][22], thiazoles, 2,3-dihydro thiazoles [4], which have been shown to exhibit antiprotozoal [11], and fungicidal properties [8].…”

Convenient Synthesis, Characterization, Cytotoxicity and Toxicity of Pyrazole Derivatives

“…[1][2][3][4][5][6] They are also acknowledged for their anticancer activities. [7][8][9] Celecoxib, sulfaphenazole, CDPPB, linazolac, mepiprazole, and rimonabant are some of the pyrazole-based drugs available today in the market ( Figure 1). 10 Moreover, the chemistry of fused pyrazole derivatives has received great attention due to their pharmacological importance.…”