Synthesis, applications and biosafety evaluation of carbon dots derived from herbal medicine

Sun, Lingxiang; Zhang, Ran; Zhang, Tong; Liu, Xiaoming; Zhao, Yifan; Yang, Mengqi; Cheng, Huaiyi; Zhang, Qingmei; Zhang, Yanjie; Wu, Xiuping; Li, Bing

doi:10.1088/1748-605x/acdeb8

Cited by 8 publications

(1 citation statement)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the preservation of medicinal value and biological activities of herbs, HM-CDs find wider applications in areas such as herbal extraction, drug delivery, and targeted therapy. 11 The structural characteristics, physicochemical qualities, and biological functions of HM-CDs vary amongst different herbal medicines. At present, multiple pharmacological experiments have demonstrated the biological effect of carbon dots in herbal medicines, which revealed the pharmacodynamic basis of herbal medicines in various diseases from a fresh perspective.…”

Section: Introductionmentioning

confidence: 99%

Potential Efficacy of Herbal Medicine-Derived Carbon Dots in the Treatment of Diseases: From Mechanism to Clinic

Zeng,

Wang,

Liu

et al. 2023

IJN

View full text Add to dashboard Cite

Carbon dots (CDs), a crucial component of nanomaterials, are zero-dimensional nanomaterials with carbon as the backbone structure and smaller than 10 nm. Due to their beneficial characteristics, they are widely used in biomedical fields such as biosensors, drug delivery, bio-imaging, and interactions with DNA. Interestingly, a novel type of carbon dot, generated by using herbal medicines as synthetic raw materials, has emerged as the most recent incomer in the family of CDs with the extensive growth in the number of materials selected for carbon dots synthesis. Herbal medicine-derived carbon dots (HM-CDs) have been employed in the biomedical industry, and are rapidly emerging as “modern nanomaterials” due to their unique structures and exceptional capabilities. Emerging trends suggest that their specific properties can be used in bleeding disorders, gastrointestinal disorders, inflammation-related diseases, and other common intractable diseases including cancer, menopausal syndrome, central nervous system disorders, and pain of various forms and causes. In addition, HM-CDs have been found to have organ-protective and antioxidant properties, as evidenced by extensive studies. This research provides a more comprehensive understanding of the biomedical applications of HM-CDs for the aforementioned disorders and investigates the intrinsic pharmacological activities and mechanisms of these HM-CDs to further advance their clinical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Potential Efficacy of Herbal Medicine-Derived Carbon Dots in the Treatment of Diseases: From Mechanism to Clinic

Zeng,

Wang,

Liu

et al. 2023

IJN

View full text Add to dashboard Cite

show abstract

Endowing Polyetheretherketone with Anti‐Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection

Bai,

Zhang,

Xiao

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Methicillin‐resistant Staphylococcus aureus (MRSA) infection and compromised immunity are the severe complications associated with implantation surgery in diabetes mellitus. Enhancing the antibacterial and immunomodulatory properties of implants represents an effective approach to improve the osseointegration of implant in diabetes mellitus. Herein, guanidination carbon dots (GCDs) with antibacterial and immunoregulatory functions are synthesized. The GCDs demonstrate killing effect on MRSA without detectable induced resistance. Additionally, they promote the polarization of macrophages from the M1 to M2 subtype, with the inhibiting pro‐inflammatory cytokines and promoting anti‐inflammatory factors. Correspondingly, GCDs are immobilized onto sulfonated polyether ether ketone (SP@GCDs) using a polyvinyl butyraldehyde (PVB) coating layer through soaking‐drying technique. SP@GCDs maintain stable antibacterial efficacy against MRSA for six consecutive days and retain the immunomodulatory function, while also possessing the long‐term storage stability and biocompatibility of more than 6 months. Moreover, SP@GCDs significantly promote the proliferation and mineralization of osteoblasts. SP@GCDs facilitate osteogenesis through immunoregulatory. Additionally, SP@GCDs exert stable antibacterial and immune regulatory functions in implantation site of a diabetes rat, effectively promoting implant osseointegration regardless of the MRSA infection. These findings provide valuable insights into implant modification through designing nanomaterials with multifunction for enhancing osseointegration of diabetes mellitus, suggesting the promising clinical application prospects.

show abstract

Carbon dots-cisplatin nano drug delivery system induces the death of oral tongue squamous cell under self-targeting chemical/photodynamic combined therapy

Wang,

Du,

Wang

et al. 2025

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Synthesis, applications and biosafety evaluation of carbon dots derived from herbal medicine

Cited by 8 publications

References 136 publications

Potential Efficacy of Herbal Medicine-Derived Carbon Dots in the Treatment of Diseases: From Mechanism to Clinic

Potential Efficacy of Herbal Medicine-Derived Carbon Dots in the Treatment of Diseases: From Mechanism to Clinic

Endowing Polyetheretherketone with Anti‐Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection

Carbon dots-cisplatin nano drug delivery system induces the death of oral tongue squamous cell under self-targeting chemical/photodynamic combined therapy

Contact Info

Product

Resources

About