Synthesis, biological activity and docking study of some new isatin Schiff base derivatives

Azizian, Javad; Mohammadi, Mohammad Kazem; Firuzi, Omidreza; Razzaghi‐Asl, Nima; Miri, Ramin

doi:10.1007/s00044-011-9896-6

Cited by 61 publications

(27 citation statements)

References 35 publications

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“…First, 1, 3-dihydro-indol-2-one (1 i a-1 i b) was synthesized, following the method reported for the synthesis of isatin [17,35,36]. For this, isatin (1) and substituted anilines were dissolved in warm ethanol in the presence of 2-3 drops of glacial acetic acid and refluxed for 2-3 h. After standing for approximately 24 h at room temperature (r.t), product was obtained.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel (2-Oxo-3-(Arylimino) Indolin-1-Yl)-N-Aryl Propanamides as Anti-Human Immunodeficiency Agents

Debnath

Wang

Yang

et al. 2018

Asian J Pharm Clin Res

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Objective: Acquired immunodeficiency syndrome (AIDS) was first identified in the Western world in 1981. Since then, AIDS has been increasingly wide spreading, its rapid worldwide dissemination brought about by modern mass tourism. Isatin (1 H-indole-2, 3-Dione), an endogenous compound identified in many organisms, shows a wide range of biological activities. In view of the above details, we wish to report the synthesis and evaluation of novel isatin analogs, as promising anti-human immunodeficiency (HIV) agents. Methods:A series of novel isatin analogs (3a-3p) were synthesized, and their chemical structures were confirmed by nuclear magnetic resonance: 1 H, 13 C, ESI-MS spectral data, and CHNS. Results:The compounds were evaluated as inhibitors of HIV type-1 in MT-4 cell cultures. Of these sixteen compounds, only 5 compounds showed potent anti-HIV activity.Conclusion: Evaluation of compound properties in silico showed that they possess significant drug-like characteristics.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel (2-Oxo-3-(Arylimino) Indolin-1-Yl)-N-Aryl Propanamides as Anti-Human Immunodeficiency Agents

Debnath

Wang

Yang

et al. 2018

Asian J Pharm Clin Res

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“…Recently, Azizian et al [34] discussed the synthesis and anticancer activity of some Schiff bases of isatins including compound 17 (Figure 12). indolinone NH with Glu915 and two oxygen atoms of nitro group with Arg1049 and Asn921 (Figure 12) [35].…”

Section: Figure 11mentioning

confidence: 99%

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Ibrahim

Abou‐Seri

Abdel‐Aziz

2016

European Journal of Medicinal Chemistry

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“…Schiff bases play an important role in the coordination and bioinorganic chemistry due to their facile preparation and versatile structures, as well as interesting biological applications. [4][5][6][7] Recently, a number of iron complexes with Schiff base ligands have been reported with respect to their syntheses, structures, and various properties. [8][9][10][11][12] However, the number of m-oxidobridged dinuclear iron(III) complexes is far from being sufficient.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Crystal Structure of a μ-Oxido-Bridged Dinuclear Iron(III) Complex Derived From 3, 5-Dichlorosalicylaldehyde and 4-(2-Aminoethyl)morpholine

Sheng

Cheng

Zhang

et al. 2014

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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2015) Synthesis and Crystal Structure of a µ-Oxido-Bridged Dinuclear Iron(III) Complex Derived From 3, 5-Dichlorosalicylaldehyde and 4-(2-Aminoethyl)morpholine, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 45:3, 388-391, A m-oxido-bridged dinuclear iron(III) complex, [Fe 2 O(L 1 ) 2 (L 2 ) 2 ], where L 1 and L 2 are the deprotonated forms of 2,4-dichloro-6-[(2-morpholin-4-ylethylimino)methyl]phenol and 3,5-dichlorosalicylaldehyde, respectively, has been prepared and characterized by elemental analysis, infrared spectrum, and single-crystal X-ray determination. The complex crystallizes in the triclinic space group P1, with unit cell dimensions a D 10.670(1) A , b D 11.585(1) A , c D 19.748(2) A , a D 86.766(2) , b D 85.038(2) , g D 73.973(2) , V D 2336.1(4) A 3 , Z D 2, GOOF D 1.019, R 1 D 0.0422, and wR 2 D 0.1024. Structural analysis shows that the iron atoms in the complex are hexacoordinate with a normal Fe-O-Fe bridging angle of 150.84(13) . Each Fe atom is coordinated by the NNO donor atoms of L 1 , OO donor atoms of L 2 , and one bridging O atom. The Fe¢ ¢ ¢Fe distance is 3.467(2) A .

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Synthesis, biological activity and docking study of some new isatin Schiff base derivatives

Cited by 61 publications

References 35 publications

Synthesis and Biological Evaluation of Novel (2-Oxo-3-(Arylimino) Indolin-1-Yl)-N-Aryl Propanamides as Anti-Human Immunodeficiency Agents

Synthesis and Biological Evaluation of Novel (2-Oxo-3-(Arylimino) Indolin-1-Yl)-N-Aryl Propanamides as Anti-Human Immunodeficiency Agents

3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents

Synthesis and Crystal Structure of a μ-Oxido-Bridged Dinuclear Iron(III) Complex Derived From 3, 5-Dichlorosalicylaldehyde and 4-(2-Aminoethyl)morpholine

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