Synthesis, biological evaluation and docking study of some novel isoxazole clubbed 1,3,4-oxadiazoles derivatives

Shingare, Ramesh; Patil, Yogesh; Sangshetti, Jaiprakash N.; Patil, Rajesh B.; Rajani, Dhanji P.; Madje, Balaji R.

doi:10.1007/s00044-018-2148-2

Cited by 22 publications

(6 citation statements)

References 18 publications

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“…16) [59]. (34)(35)(36)(37)(38) showed almost better antibacterial activity as compared to standard drug Ampicillin and lesser towards antifungal drug Griseofulvin (Table 18) [61]. 20).…”

Section: Antibacterial and Antifungal Activities Of 25-disubstituted-...mentioning

confidence: 98%

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Antimicrobial Activity and Sar of 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

Kumar

Narang

Devgun

et al. 2022

JASR

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1,3,4-oxadiazole is a five membered heterocyclic aromatic moiety, present in a number of antimicrobial agents. 2,5- disubstituted 1,3,4-oxadiazole derivatives have shown broad spectrum of antibacterial and antifungal activities. Many scientific groups have synthesized and screened their antimicrobial potential. Reported activity data showed that some 1,3,4-oxadiazole derivatives exhibited better activity than already known antibiotics. Hence, they can be used as lead for development of promising antimicrobial agents. In present review, antimicrobial activities and SAR of 2,5-disubstituted 1,3,4-oxadiazole derivatives reported by different research groups in last ten years have been summarized.

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“…16) [59]. (34)(35)(36)(37)(38) showed almost better antibacterial activity as compared to standard drug Ampicillin and lesser towards antifungal drug Griseofulvin (Table 18) [61]. 20).…”

Section: Antibacterial and Antifungal Activities Of 25-disubstituted-...mentioning

confidence: 98%

“…Ciprofloxacin but lower against E. faecalis (MIC = 250 µg/mL) (Table26). Whereas, compounds(61)(62)(63)(64)(65) showed less antifungal activity against C. albicans and A. niger (MIC = 250 µm/mL) as compared to standard drug Fluconazole. Overall it can be concluded that…”

mentioning

confidence: 99%

Antimicrobial Activity and Sar of 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

Kumar

Narang

Devgun

et al. 2022

JASR

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“…Shingare et al [ 89 ] synthesized isoxazole clubbed 1,3,4‐oxadiazoles 26 and 27 and evaluated for their antitubercular activity against MTB H 37 Rv. Compounds 26 and 27 showed good antitubercular activity with MIC of 62.5 and 50 µg/ml due to the presence of methoxy group at the second position of the phenyl ring in compound 26 and the presence of fluorine atom at the fourth position in the phenyl ring in compound 27 (Figure 15).…”

Section: Medicinal Attributes Of Oxadiazole Derivativesmentioning

confidence: 99%

Oxadiazole: A highly versatile scaffold in drug discovery

Desai

Monapara

Jethawa

et al. 2022

Archiv der Pharmazie

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As a pharmacologically important heterocycle, oxadiazole paved the way to combat the problem associated with the confluence of many commercially available drugs with different pharmacological profiles. The present review focuses on the potential applications of five-membered heterocyclic oxadiazole derivatives, especially 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole, as therapeutic agents. Designing new hybrid molecules containing the oxadiazole moiety is a better solution for the development of new drug molecules. The designed molecules may accumulate a biological profile better than those of the drugs currently available on the market. The present review will guide the way for researchers in the field of medicinal chemistry to design new biologically active molecules based on the oxadiazole nucleus. Antitubercular, antimalarial, anti-inflammatory, anti-HIV, antibacterial, and anticancer activities of various oxadiazoles have been reviewed extensively here.

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“…In contrast, compounds 12f and 12g (Figure 6) showed antimycobacterial activity against the M. tuberculosis H37Rv strain. Additionally, molecular docking studies were conducted to gain insight inhibition of the MurD ligase enzyme which is involved in the biosynthesis of cytoplasmic peptidoglycan precursor [46]. Das et al (2020) synthesized a series of pyrazine containing 1,3,4-oxadiazoles with substituted azetidin-2-one.…”

Section: Antibacterial Activity Of Aryl/heteroaryl Derivatives Of 134-oxadiazolementioning

confidence: 99%

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives

Glomb

Świątek

2021

IJMS

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The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1,3,4-oxadiazole ring, which have shown various antimicrobial activity, e.g., antibacterial, antitubercular, antifungal, antiprotozoal and antiviral. In many publications, the activity of new compounds exceeds the activity of already known antibiotics and other antimicrobial agents, so their potential as new drugs is very promising. The review of active antimicrobial 1,3,4-oxadiazole derivatives is based on the literature from 2015 to 2021.

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Synthesis, biological evaluation and docking study of some novel isoxazole clubbed 1,3,4-oxadiazoles derivatives

Cited by 22 publications

References 18 publications

Antimicrobial Activity and Sar of 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

Antimicrobial Activity and Sar of 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

Oxadiazole: A highly versatile scaffold in drug discovery

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives

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