Synthesis, biological evaluation and molecular docking study of 1,2,3-1H-triazoles having 4H-pyrano[2,3-d]pyrimidine as potential Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors

Ecofriendly synthesis of pyrano[2,3‐d]pyrimidine derivatives and related heterocycles with anti‐inflammatory activities

“…Pyrano [2,3-d]pyrimidine nucleus has a variety of important biological applications such as anticancer, [1,2] antimicrobial, [3] antioxidant, [4] biofilm inhibition assay, [5] antigenotoxic, [6] and antiviral. [7] However, pyran and its derivatives have significant and different biological activities.…”

“…|11 of 13 aromatic and aliphatic), 1,689 cm −1 (C═O for amide), 1,158 cm −1 (C═S), and 1,539 (C═N) cm -1 1. H NMR (DMSO-d 6 , 400 MHz): δ = 3.35 (s, 1H, CH-Ph methine), 7.27-7.75 (m, 9H, ArH), 8.25 (s, 1H, CH═N), 8.61 (s, 1H, NH═C), 11.42, 12.18 (2s, 2H, NH exchangeable by D 2 O).…”

Synthesis, pharmacological evaluation and structure-activity relationship of recently discovered enzyme antagonist azoles

“…Further, these enzymes can be utilized as clinical targets for the design and development of potential drug molecules. Taken together with the medicinal properties of pyrano [2,3-d]pyrimidine moiety towards anti-tubercular activity and decent MTB PtpB inhibitory activity of 1,2,3-1H-triazole, a structural framework is designed anticipating better MTB PtpB inhibitory activity [2].…”

“…Scheme 2. Synthetic route for preparation of 1,2,3-1H-triazoles derivatized 4H-pyrano [2,3-d] pyrimidine analogs [2]; Reagents and conditions: (a) Ammonium solution 25%, 25 C, 3 h, or Cu@MOF-5 (10 mol%), 96% EtOH, 50 Inhibition of tumoral carbonic anhydrases (CA) could lead to slowdown of metastasis and reduced cancer symptoms. However, most of the discovered CA inhibitors have also inhibited isoforms of CA and thereby reduced efficiencies are observed.…”

Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

“…1 ). Alternatively, pyranopyrimidine heterocycles have significant and confidential biological and physiological potency since this class of compounds demonstrated antibacterial, antitumor, 1–3 antimicrobial, 4–7 anti-inflammatory, 8,9 antioxidant, antidiabetic, 10,11 tyrosine phosphatase inhibitors, 12 antitubercular, 13 Hh signaling inhibitors in NIH3T3 cells, 14 antihypertensive, 15 antimalarial, 16 antiviral, 17 anticancer, 18,19 and cardiotonic agents. 20,21…”