SYNTHESIS, CHARACTERISATION AND ANTIDIABETIC SCREENING OF Co(II),Cu(II),Zn(II) AND La(II) COMPLEXES OF GLIMEPERIDEA STANDARD SYNTHETIC ALLOPATHIC DRUG

Abstract

Metal complxes of Glimeperide drugs were prepared and characterized based on elemental analysis, FT-IR, Molar conductance and thermal analysis (TGA and DTG) technique. From elemental analysis data, the complexes were proposed to have general formulae (GLM)2Co2H2O, (GLM)2Cu, (GLM)2Zn, and (GLM)2La2H2O. The molar conductance data reveal that all the metal complexes are non-electrolytic, IR spectra shows that GLM are coordinated to metal ions in a neutral bidentate manner from the ESR spectra and XRDspectra. It is found that the geometrical structures of these complexes are tetrahedral Cu(II) ,Zn(II) and octrahedral Co(II), La(II). The thermal behavior of these complexes studied using thermogravimetric analysis (TGA and DTG) techniques. The results obtained shows that the hydrated complexes lose water molecules of hydration followed immediately by decomposition of the anions and ligand molecules in the successive unseparate steps. Thermogravimetric analysis was carried out to study the decomposition and various kinetic parameters. Freeman Carroll and Sharp Wentworth method have been applied for calculation of kinetic parameters.While data from freeman Carroll method have been used to determine various thermodynamic parameters such as order of reactions, energy of activation, frequency factor, entropy change, free energy change and apparent entropy change and order of reaction..