Synthesis, Characterisation and Antifungal Activities of Some New Copper(II) Complexes of Isomeric 3,5,7,7,10,12,14,14‐Octamethyl‐1,4,8,11‐Tetraazacyclotetradecanes

Abstract

Three isomeric Me8[14]anes, LA, LB and LC, undergo complexation with copper(II) salts to form a series of [CuLXn(H2O)x]Xy.(H2O)z complexes where L = LA, LB and LC; X = Cl, Br, NO3; n, x, y and z may have values of 0, 1 or 2. The complexes have been characterised on the basis of analytical, spectroscopic, magnetic and conductance data. Further, the X-ray crystal structure of one complex, [CuLB(OH2)2](NO3)2, has been determined. The antifungal activity of all three isomeric ligands and their complexes has been investigated against a range of phytopathogenic fungi.

Synthesis, electrolytic behaviour and antimicrobial activities of cadmium complexes of isomers of 3,10-C- meso -3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane

“…In another study, Tapashi and coworkers [10,11] prepared a six-coordinate copper(II) complex of the parent diene ligand of formula [CuL 2 (ClO 4 ) 2 ] Á 2H 2 O (L 2 ¼ Me 8 [14]diene) and its axial ligand substitution products of general formula [CuL 2 (ClO 4 ) m X n ], where X ¼ NCS À , Cl À , or NO À 3 , m ¼ 0 or 1 and n ¼ 1 or 2. 2 have been confirmed by X-ray analysis [9,12]. Recently six-coordinate zinc(II) complexes of general formula [ZnL 1 X 2 ]Y n (X ¼ NO À 3 , H 2 O or Cl À , Y ¼ SO 2À 4 or Cl À , n ¼ 0, 1 or 2), a diaquo perchlorate complex with L B , [ZnL B (H 2 O) 2 ](ClO 4 ) 2 and its axial substitution reaction products have been synthesized; where water molecules are substituted by other ligands like NCS À , ClO À 4 , NO À 2 and NO À 3 [13].…”

“…The spectra further display bands at 1440-1460 cm À1 and 1325-1345 cm À1 attributed to coordinated NO À 3 . The separation of these bands by 115 cm À1 indicates unidentate mode of coordination [9,11,17]. Though NO À 3 can also coordinate as a bidentate ligand [18], this is not possible in this case, because the macrocycle needs to be folded which is difficult due to steric hindrance of eight peripheral methyl groups present.…”

“…X-ray structure of one dinitrito substitution product [CoL A (NO 2 ) 2 ](ClO 4 ) has been reported [8]. Hazari and coworkers [9] prepared some new four-and six-coordinate copper(II) complexes of general formula [CuL 1 X n (H 2 O) x ]X y Á (H 2 O) z , (X ¼ Cl À , Br À or NO À 3 ; n, x, y and z ¼ 0, 1 or 2). In another study, Tapashi and coworkers [10,11] prepared a six-coordinate copper(II) complex of the parent diene ligand of formula [CuL 2 (ClO 4 ) 2 ] Á 2H 2 O (L 2 ¼ Me 8 [14]diene) and its axial ligand substitution products of general formula [CuL 2 (ClO 4 ) m X n ], where X ¼ NCS À , Cl À , or NO À 3 , m ¼ 0 or 1 and n ¼ 1 or 2.…”

Two solvatomorphic forms of a copper complex formulated as Cu(L1)(ClO4)2·1.2H2O and Cu(L1)(ClO4)2, whereL1is 3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane

“…CSD refode (Reference) Space group Cation (symmetry) Sequence (type) DEFJIH (Lee et al, 1985) P2 1 /c Cu (1) RRRR-SSSS (1) OCMENH (Ferguson et al, 1990) P2 1 /n Ni (1) RRRR-SSSS (1) POTPUJ (Hazari et al, 1997) P2 1 /c Cu (1) RRRR-SSSS (1) QOPJIO (Horn et al, 2001) P1…”

N-functionalized cyclam based trinuclear copper(II) complexes: electrochemical, magnetic, catalytic and antimicrobial studies

“…The screening data were reported in the Table 4. All the complexes show some antifungal activity, comparable with the N-substituted tetraazamacrocycles [51][52][53].…”