Synthesis, Characterisation and Biological Activity of a New Mannich Base and It’s Metal Complexes

Abstract

Mannich bases play a major role in biological processes. In view of this a new Mannich base 1-(2,5-dioxo pyrolidin-1-yl)(4-methoxy phenyl)(methyl)thiourea (SMBTU) was synthesized using succinimide, methoxybenzaldehyde and thiourea. The complexation behaviour of this ligand with Mn(II), Ni(II), Cu(II) and Zn(II) ions were studied. The structural features of the complexes were analyzed by elemental analysis, IR, UV-Visible, 1 H, 13 C NMR spectra and magnetic susceptibility measurements. The anti microbial activity of the ligand and its complexes has been extensively studied against some of the gram-positive and gram-negative bacterium. The ligand and all the metal complexes showed antimicrobial activity.