Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy

Karges, Johannes; Gasser, Gilles

doi:10.1016/j.ica.2019.119196

Cited by 13 publications

(12 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 TLC1433 is one member of a family of transition metal coordination complexes currently being developed for PDT. [22][23][24][25] The drug uptake selectivity was previously determined to be 0.4 AE 0.06 mg kg −1 in normal bladder comprising urothelium, mucosa, and muscle and 77 AE 18 mg kg −1 in AY-27 rat bladder wall tumor. The resulting selective uptake ratio (SUR) is 192.…”

Section: Introductionmentioning

confidence: 99%

Minimal required PDT light dosimetry for nonmuscle invasive bladder cancer

Lilge

et al. 2020

J. Biomed. Opt.

View full text Add to dashboard Cite

Significance: Photodynamic therapy (PDT) could become a treatment option for nonmuscle invasive bladder cancer when the current high morbidity rate associated with red light PDT and variable PDT dose can be overcome through a combination of intravesical instillation of the photosensitizer and the use of green light creating a steep PDT dose gradient. Aim: To determine how a high PDT selectivity can be maintained throughout the bladder wall considering other efficacy determining parameters, in particular, the average optical properties of the mucosal layer governing the fluence rate multiplication factor, as well as the bladder shape and the position of the emitter in relationship to the bladder wall. Approach: We present three irradiance monitoring systems and evaluate their ability to enable selective bladder PDT considering previously determined photodynamic threshold values for the bladder cancer, mucosa and urothelium in a preclinical model, and the photosensitizer's specific uptake ratio. Monte Carlo-based light propagation simulations performed for six human bladders at the time of therapy for a range of tissue optical properties. The performance of one irradiance sensing device in a clinical phase 1B trial is presented to underline the impact of irradiance monitoring, and it is compared to the Monte Carlo-derived dose surface histogram. Results: Monte Carlo simulations showed that irradiance monitoring systems need to comprise at least three sensors. Light scattering inside the bladder void needs to be minimized to prevent increased heterogeneity of the irradiance. The dose surface histograms vary significantly depending on the bladder shape and bladder volume but are less dependent on tissue optical properties. Conclusions: We demonstrate the need for adequate irradiance monitoring independent of a photosensitizer's specific uptake ratio.

show abstract

Section: Introductionmentioning

confidence: 99%

Minimal required PDT light dosimetry for nonmuscle invasive bladder cancer

Lilge

et al. 2020

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

“…66 In 2020, Fe( ii ) polypyridine complexes with an extension of the π-system were designed to achieve red-shifted absorption into the biological spectral window (600–900 nm). 90 However, the complexes were poor singlet oxygen generators and only displayed a slight cytotoxicity enhancement upon exposure to 480 and 540 nm light in HeLa cells. Although not as well developed as for manganese, phototoxic iron-based photoCORMs have also been studied.…”

Section: Phototoxic First-row Transition Metal Complexesmentioning

confidence: 99%

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…With this aim in mind, we have recently investigated the use of Fe(II) polypyridine complexes as potential PDT PSs. 70,71 Based on the clinical success of tetrapyrrolic compounds and the high potential of transition metal complexes, it would be of great interest to combine both concepts by preparing bis(dipyrrinato)metal(II) complexes based on cheap, abundant metals. In this context, we have recently described bis(dipyrrinato)Zn(II) complexes with exceptionally long excited state lifetimes.…”

Section: Introductionmentioning

confidence: 99%